Phosphate carrier protein, mitochondrial

SLC25A3
Identifiers
Aliases	SLC25A3, PHC, PTP, OK/SW-cl.48, solute carrier family 25 member 3
External IDs	OMIM: 600370; MGI: 1353498; HomoloGene: 37649; GeneCards: SLC25A3; OMA:SLC25A3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	98,606,379 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	90,959,921 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; apex of heart; ; cardiac muscle tissue of right atrium; ; right ventricle; ; tibialis anterior muscle; ; mucosa of ileum; ; right adrenal gland; ; right adrenal cortex; ; deltoid muscle; ; left adrenal gland;
	Top expressed in
	muscle of thigh; ; right kidney; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; lip; ; neural layer of retina; ; esophagus; ; ventricular zone; ; embryo; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-containing complex binding; symporter activity; inorganic phosphate transmembrane transporter activity; phosphate:proton symporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; myelin sheath; integral component of plasma membrane; extracellular exosome; membrane; mitochondrion; mitochondrial inner membrane; integral component of mitochondrial inner membrane;
Biological process	transmembrane transport; phosphate ion transmembrane transport; mitochondrial transport; transport; proton transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	5250
	18674
	ENSG00000075415
	ENSMUSG00000061904
	Q00325
	Q8VEM8
	NM_213612; NM_002635; NM_005888; NM_213611
	NM_133668
	NP_002626; NP_005879; NP_998776; NP_005879.1
	NP_598429
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphate carrier protein, mitochondrial is a protein that in humans is encoded by the SLC25A3 gene. The encoded protein is a transmembrane protein located in the mitochondrial inner membrane and catalyzes the transport of phosphate ions across it for the purpose of oxidative phosphorylation. There are two significant isoforms of this gene expressed in human cells, which differ slightly in structure and function. Mutations in this gene can cause mitochondrial phosphate carrier deficiency (MPCD), a fatal disorder of oxidative phosphorylation symptomized by lactic acidosis, neonatal hypotonia, hypertrophic cardiomyopathy, and death within the first year of life.