Mitoferrin-1

SLC25A37
Identifiers
Aliases	SLC25A37, MFRN, MFRN1, MSC, MSCP, PRO1278, PRO1584, PRO2217, HT015, solute carrier family 25 member 37
External IDs	OMIM: 610387; MGI: 1914962; HomoloGene: 74739; GeneCards: SLC25A37; OMA:SLC25A37 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	23,575,463 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	69,522,561 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; blood; ; bone marrow; ; monocyte; ; vena cava; ; mucosa of paranasal sinus; ; sperm; ; jejunal mucosa; ; duodenum; ; pericardium;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; human fetus; ; blood; ; tibiofemoral joint; ; umbilical cord; ; body of femur; ; spleen; ; atrioventricular valve; ; atrium; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion transmembrane transporter activity; transmembrane transporter activity;
Cellular component	membrane; mitochondrion; mitochondrial inner membrane; integral component of membrane;
Biological process	ion transport; iron ion homeostasis; mitochondrial transport; iron import into the mitochondrion;
	Sources:Amigo / QuickGO
Orthologs
	51312
	67712
	ENSG00000147454
	ENSMUSG00000034248
	Q9NYZ2
	Q920G8
NM_016612; NM_001317812; NM_001317813; NM_001317814; NM_018579;
	NM_018586
	NM_026331; NM_030054
	NP_001304741; NP_001304742; NP_001304743; NP_057696
	NP_080607
	Wikidata
View/Edit Human	View/Edit Mouse

Mitoferrin-1 (Mfrn1) is a 38 kDa protein that is encoded by the SLC25A37 gene in humans. It is a member of the Mitochondrial carrier (MC) Superfamily, however, its metal cargo makes it distinct from other members of this family. Mfrn1 plays a key role in mitochondrial iron homeostasis as an iron transporter, importing ferrous iron from the intermembrane space of the mitochondria to the mitochondrial matrix for the biosynthesis of heme groups and Fe-S clusters. This process is tightly regulated, given the redox potential of Mitoferrin's iron cargo. Mfrn1 is paralogous to Mitoferrin-2 (Mfrn2), a 39 kDa protein encoded by the SLC25A28 gene in humans. Mfrn1 is highly expressed in differentiating erythroid cells and in other tissues at low levels, while Mfrn2 is expressed ubiquitously in non-erythroid tissues.