Sulfate transporter

SLC26A2
Identifiers
Aliases	SLC26A2, D5S1708, DTD, DTDST, EDM4, MST153, MSTP157, solute carrier family 26 member 2
External IDs	OMIM: 606718; MGI: 892977; HomoloGene: 73876; GeneCards: SLC26A2; OMA:SLC26A2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	149,993,455 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	61,344,684 bp
RNA expression pattern
	Top expressed in
	mucosa of colon; ; mucosa of sigmoid colon; ; mucosa of transverse colon; ; rectum; ; seminal vesicula; ; mucosa of paranasal sinus; ; trigeminal ganglion; ; mucosa of ileum; ; skin of thigh; ; corpus epididymis;
	Top expressed in
	left colon; ; lacrimal gland; ; ileum; ; epithelium of stomach; ; salivary gland; ; parotid gland; ; transitional epithelium of urinary bladder; ; jejunum; ; rib; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	secondary active sulfate transmembrane transporter activity; bicarbonate transmembrane transporter activity; oxalate transmembrane transporter activity; chloride channel activity; sulfate transmembrane transporter activity; chloride transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; extracellular exosome; integral component of plasma membrane; plasma membrane; apical plasma membrane; microvillus membrane;
Biological process	ossification; regulation of membrane potential; regulation of intracellular pH; chloride transmembrane transport; ion transport; bicarbonate transport; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; oxalate transport; transmembrane transport; sulfate transport; sulfate transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	1836
	13521
	ENSG00000155850
	ENSMUSG00000034320
	P50443
	Q62273
	NM_000112
	NM_007885
	NP_000103
	NP_031911
	Wikidata
View/Edit Human	View/Edit Mouse

The sulfate transporter is a solute carrier family protein that in humans is encoded by the SLC26A2 gene. SLC26A2 is also called the diastrophic dysplasia sulfate transporter (DTDST), and was first described by Hästbacka et al. in 1994. A defect in sulfate activation described by Superti-Furga in achondrogenesis type 1B was subsequently also found to be caused by genetic variants in the sulfate transporter gene. This sulfate (SO₄²⁻) transporter also accepts chloride, hydroxyl ions (OH⁻), and oxalate as substrates. SLC26A2 is expressed at high levels in developing and mature cartilage, as well as being expressed in lung, placenta, colon, kidney, pancreas and testis.