Prestin

SLC26A5
Identifiers
Aliases	SLC26A5, DFNB61, PRES, solute carrier family 26 member 5
External IDs	OMIM: 604943; MGI: 1933154; HomoloGene: 69472; GeneCards: SLC26A5; OMA:SLC26A5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	103,446,207 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	22,070,602 bp
RNA expression pattern
	Top expressed in
	testicle; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; gonad; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; lactiferous gland; ; zone of skin; ; skin of leg;
	Top expressed in
	zygote; ; secondary oocyte; ; embryo; ; morula; ; yolk sac; ; blastocyst; ; primary oocyte; ; epiblast; ; superior frontal gyrus; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	spectrin binding; protein homodimerization activity; sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; bicarbonate transmembrane transporter activity; oxalate transmembrane transporter activity; chloride channel activity; transcription factor binding; chloride transmembrane transporter activity;
Cellular component	cytoplasm; integral component of membrane; lateral plasma membrane; membrane; plasma membrane; integral component of plasma membrane; basolateral plasma membrane;
Biological process	cochlea development; response to potassium ion; positive regulation of cell motility; sulfate transport; regulation of membrane potential; response to thyroid hormone; regulation of intracellular pH; chloride transmembrane transport; hearing; protein tetramerization; negative regulation of ion transmembrane transport; bicarbonate transport; ion transmembrane transport; response to ischemia; anion transmembrane transport; response to salt; transmembrane transport; positive regulation of cell size; regulation of cell shape; response to auditory stimulus; response to salicylic acid; fructose transmembrane transport; oxalate transport; sulfate transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	375611
	80979
	ENSG00000170615
	ENSMUSG00000029015
	P58743
	Q99NH7
NM_001167962; NM_198999; NM_206883; NM_206884; NM_206885;
	NM_001321787
	NM_030727; NM_001289787; NM_001289788
NP_001161434; NP_001308716; NP_945350; NP_996766; NP_996767;
	NP_996768
	NP_001276716; NP_001276717; NP_109652
	Wikidata
View/Edit Human	View/Edit Mouse

Prestin is a protein that is critical to sensitive hearing in mammals. It is encoded by the SLC26A5 (solute carrier anion transporter family 26, member 5) gene.

Prestin is the motor protein of the outer hair cells of the inner ear of the mammalian cochlea. It is highly expressed in the outer hair cells, and is not expressed in the nonmotile inner hair cells. Immunolocalization shows prestin is expressed in the lateral plasma membrane of the outer hair cells, the region where electromotility occurs. The expression pattern correlates with the appearance of outer hair cell electromotility.