SLC26A6

SLC26A6
Identifiers
Aliases	SLC26A6, solute carrier family 26 member 6
External IDs	OMIM: 610068; MGI: 2159728; HomoloGene: 99903; GeneCards: SLC26A6; OMA:SLC26A6 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	48,635,493 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	108,742,117 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; ascending aorta; ; oocyte; ; rectum; ; stromal cell of endometrium; ; left coronary artery; ; body of stomach;
	Top expressed in
	duodenum; ; jejunum; ; ileum; ; primary oocyte; ; yolk sac; ; pancreas; ; muscle tissue; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	PDZ domain binding; formate transmembrane transporter activity; chloride transmembrane transporter activity; anion transmembrane transporter activity; sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; bicarbonate transmembrane transporter activity; formate efflux transmembrane transporter activity; oxalate transmembrane transporter activity; protein binding; efflux transmembrane transporter activity; antiporter activity; chloride channel activity; inorganic anion exchanger activity;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; vesicle membrane; plasma membrane; integral component of plasma membrane; chloride channel complex; brush border membrane; basolateral plasma membrane; apical plasma membrane; endoplasmic reticulum; sperm midpiece; cytoplasmic vesicle membrane; cytoplasmic vesicle; intracellular anatomical structure; vesicle;
Biological process	oxalic acid secretion; mannitol transport; oxalate transport; formate transport; intracellular pH elevation; sulfate transport; epithelial fluid transport; angiotensin-activated signaling pathway; regulation of membrane potential; regulation of intracellular pH; cellular response to fructose stimulus; ion transport; transepithelial chloride transport; protein kinase C signaling; anion transport; transepithelial transport; cellular response to interferon-gamma; sperm capacitation; intestinal absorption; chloride transport; positive regulation of dipeptide transmembrane transport; cellular response to cAMP; anion transmembrane transport; sulfate transmembrane transport; bicarbonate transport; transmembrane transport; chloride transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	65010
	171429
	ENSG00000225697
	ENSMUSG00000023259
	Q9BXS9
	Q8CIW6
NM_134426; NM_001040454; NM_001281732; NM_001281733; NM_022911;
	NM_134263
	NM_134420
NP_001035544; NP_001268661; NP_001268662; NP_075062; NP_599025;
	NP_602298; NP_001035544.1
	NP_599252; NP_001395316
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.