SLC27A5

SLC27A5
Identifiers
Aliases	SLC27A5, ACSB, ACSVL6, BACS, BAL, FACVL3, FATP-5, FATP5, VLACSR, VLCS-H2, VLCSH2, solute carrier family 27 member 5
External IDs	OMIM: 603314; MGI: 1347100; HomoloGene: 7596; GeneCards: SLC27A5; OMA:SLC27A5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	58,512,413 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	12,732,119 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; nucleus accumbens; ; anterior cingulate cortex; ; Amygdala; ; caudate nucleus; ; putamen; ; left testis; ; right frontal lobe; ; right testis; ; C1 segment;
	Top expressed in
	left lobe of liver; ; gallbladder; ; sexually immature organism; ; morula; ; embryo; ; yolk sac; ; blastocyst; ; duodenum; ; cerebellar cortex; ; medial head of gastrocnemius muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; fatty acid transmembrane transporter activity; cholate-CoA ligase activity; ligase activity; catalytic activity; very long-chain fatty acid-CoA ligase activity; ATP binding; long-chain fatty acid-CoA ligase activity; protein-containing complex binding; long-chain fatty acid transporter activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; integral component of endoplasmic reticulum membrane; basal plasma membrane; endoplasmic reticulum; protein-containing complex;
Biological process	lipid metabolism; very long-chain fatty acid metabolic process; fatty acid transport; fatty acid metabolic process; ketone body biosynthetic process; bile acid and bile salt transport; long-chain fatty acid import across plasma membrane; metabolism; long-chain fatty acid metabolic process; bile acid biosynthetic process; triglyceride mobilization; bile acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10998
	26459
	ENSG00000083807
	ENSMUSG00000030382
	Q9Y2P5
	Q4LDG0
	NM_012254; NM_001321196
	NM_009512
	NP_001308125; NP_036386
	NP_033538
	Wikidata
View/Edit Human	View/Edit Mouse

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene.

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog.