Zinc transporter 3

SLC30A3
Identifiers
Aliases	SLC30A3, ZNT3, solute carrier family 30 member 3
External IDs	OMIM: 602878; MGI: 1345280; HomoloGene: 74470; GeneCards: SLC30A3; OMA:SLC30A3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	27,275,817 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	31,265,581 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; Brodmann area 10; ; left testis; ; right testis; ; endothelial cell; ; right frontal lobe; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; Brodmann area 46; ; middle temporal gyrus;
	Top expressed in
	entorhinal cortex; ; perirhinal cortex; ; zygote; ; CA3 field; ; visual cortex; ; primary visual cortex; ; secondary oocyte; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; Ileal epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	ABC-type zinc transporter activity; protein binding; cation transmembrane transporter activity; zinc ion transmembrane transporter activity;
Cellular component	synapse; integral component of plasma membrane; late endosome membrane; lysosomal membrane; synaptic vesicle membrane; cytoplasm; endosome; cell junction; lysosome; integral component of membrane; late endosome; membrane; cytoplasmic vesicle; neuron projection; synaptic vesicle; integral component of synaptic vesicle membrane; hippocampal mossy fiber to CA3 synapse; glutamatergic synapse; plasma membrane;
Biological process	response to zinc ion; ion transport; positive regulation of transport; cation transport; regulation of sequestering of zinc ion; cation transmembrane transport; zinc ion transport; zinc ion transmembrane transport; transmembrane transport; zinc ion import into synaptic vesicle;
	Sources:Amigo / QuickGO
Orthologs
	7781
	22784
	ENSG00000115194
	ENSMUSG00000029151
	Q99726
	P97441
	NM_003459; NM_001318949; NM_001318950; NM_001318951
	NM_011773; NM_001347323
	NP_001305878; NP_001305879; NP_001305880; NP_003450
	NP_001334252; NP_035903
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc transporter 3 also known as solute carrier family 30 member 3 is a protein in humans that is encoded by the SLC30A3 gene.

The SLC30A3 gene codes for the ZnT-3 SLC30A family membrane transport protein. ZnT-3 is required for the accumulation of zinc ions inside synaptic vesicles. In mice, ZnT-3 is required for some forms of memory that depend on the hippocampus and the amygdala. Zinc transport by ZnT-3 modulates memory formation by acting through the extracellular signal-regulated kinases signaling pathway. Angiotensin II-induced senescence of vascular smooth muscle cells requires down-regulation of ZnT-3 and ZnT-10.