Zinc transporter 8

SLC30A8
Identifiers
Aliases	SLC30A8, ZNT8, ZnT-8, solute carrier family 30 member 8
External IDs	OMIM: 611145; MGI: 2442682; HomoloGene: 13795; GeneCards: SLC30A8; OMA:SLC30A8 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	117,176,714 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	52,199,194 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; pancreatic epithelial cell; ; testicle; ; body of pancreas; ; tibialis anterior muscle; ; mucosa of ileum; ; gonad; ; right testis; ; left testis; ; deltoid muscle;
	Top expressed in
	islet of Langerhans; ; embryo; ; right kidney; ; foregut; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; cation transmembrane transporter activity; zinc ion binding; protein binding; zinc ion transmembrane transporter activity;
Cellular component	integral component of membrane; Golgi apparatus; secretory granule membrane; membrane; plasma membrane; transport vesicle membrane; secretory granule; cytoplasmic vesicle;
Biological process	response to interleukin-1; response to interferon-gamma; glucose homeostasis; regulation of vesicle-mediated transport; zinc ion transport; response to zinc ion; cation transport; insulin secretion; ion transport; response to glucose; cation transmembrane transport; sequestering of zinc ion; cellular zinc ion homeostasis; regulation of sequestering of zinc ion; positive regulation of insulin secretion; zinc ion transmembrane transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	169026
	239436
	ENSG00000164756
	ENSMUSG00000022315
	Q8IWU4
	Q8BGG0
	NM_001172811; NM_001172813; NM_001172814; NM_001172815; NM_173851
	NM_172816
	NP_001166282; NP_001166284; NP_001166285; NP_001166286; NP_776250
	NP_766404
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc transporter 8 (ZNT8) is a protein that in humans is encoded by the SLC30A8 gene. ZNT8 is a zinc transporter related to insulin secretion in humans. In particular, ZNT8 is critical for the accumulation of zinc into beta cell secretory granules and the maintenance of stored insulin as tightly packaged hexamers. Certain alleles of the SLC30A8 gene may increase the risk for developing type 2 diabetes, but a loss-of-function mutation appears to greatly reduce the risk of diabetes.