SLC45A4

SLC45A4
Identifiers
Aliases	SLC45A4, solute carrier family 45 member 4
External IDs	MGI: 2146236; HomoloGene: 69908; GeneCards: SLC45A4; OMA:SLC45A4 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	141,308,305 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	73,517,611 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; endothelial cell; ; blood; ; retinal pigment epithelium; ; postcentral gyrus; ; Brodmann area 23; ; middle temporal gyrus; ; primary visual cortex; ; Achilles tendon; ; bronchial epithelial cell;
	Top expressed in
	submandibular gland; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; facial motor nucleus; ; vastus lateralis muscle; ; molar; ; triceps brachii muscle; ; extraocular muscle; ; vestibular membrane of cochlear duct; ; olfactory epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	sucrose:proton symporter activity;
Cellular component	membrane; integral component of membrane;
Biological process	sucrose transport;
	Sources:Amigo / QuickGO
Orthologs
	57210
	106068
	ENSG00000022567
	ENSMUSG00000079020
	Q5BKX6
	Q0P5V9
	NM_001080431; NM_001286646; NM_001286648
	NM_001033219; NM_001168255; NM_001357747
	NP_001073900; NP_001273575; NP_001273577
	NP_001028391; NP_001161727; NP_001344676
	Wikidata
View/Edit Human	View/Edit Mouse

SLC45A4 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can: (i) transport a disaccharide, sucrose, as well simple sugars such as glucose and fructose (ii) perform secondary active transport in a proton-dependent manner.

It is associated with sugar transport in the spermatozoa. Additionally, it has been identified as a necessary component in the cell death caused of the compound paraquat.