Proton-coupled folate transporter

SLC46A1
Identifiers
Aliases	SLC46A1, G21, HCP1, PCFT, solute carrier family 46 member 1
External IDs	OMIM: 611672; MGI: 1098733; HomoloGene: 41693; GeneCards: SLC46A1; OMA:SLC46A1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,407,197 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,362,885 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; right lobe of liver; ; right uterine tube; ; body of pancreas; ; anterior pituitary; ; islet of Langerhans;
	Top expressed in
	duodenum; ; morula; ; blastocyst; ; right kidney; ; choroid plexus of fourth ventricle; ; neural layer of retina; ; parotid gland; ; left lobe of liver; ; jejunum; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; folic acid binding; proton transmembrane transporter activity; methotrexate transmembrane transporter activity; folic acid transmembrane transporter activity; heme transmembrane transporter activity;
Cellular component	cytoplasm; integral component of membrane; membrane; cell surface; brush border membrane; apical plasma membrane; plasma membrane;
Biological process	folate import across plasma membrane; proton transmembrane transport; heme transport; folic acid metabolic process; intestinal folate absorption; cellular iron ion homeostasis; folic acid transport; methotrexate transport; transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	113235
	52466
	ENSG00000076351
	ENSMUSG00000020829
	Q96NT5
	Q6PEM8
	NM_001242366; NM_080669
	NM_026740
	NP_001229295; NP_542400
	NP_081016
	Wikidata
View/Edit Human	View/Edit Mouse

The proton-coupled folate transporter is a protein that in humans is encoded by the SLC46A1 gene. The major physiological roles of PCFTs are in mediating the intestinal absorption of folate (Vitamin B9), and its delivery to the central nervous system.