Sugar transporter SWEET1

SLC50A1
Identifiers
Aliases	SLC50A1, HsSWEET1, RAG1AP1, SCP, SWEET1, slv, solute carrier family 50 member 1
External IDs	OMIM: 613683; MGI: 107417; HomoloGene: 40647; GeneCards: SLC50A1; OMA:SLC50A1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,138,857 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,177,877 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; body of pancreas; ; right adrenal gland; ; islet of Langerhans; ; right adrenal cortex; ; left adrenal gland; ; right lobe of liver; ; beta cell; ; left adrenal cortex;
	Top expressed in
	ankle joint; ; primary visual cortex; ; superior frontal gyrus; ; Ileal epithelium; ; lip; ; islet of Langerhans; ; carotid body; ; epithelium of stomach; ; right kidney; ; parotid gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	glucoside transmembrane transporter activity; sugar transmembrane transporter activity;
Cellular component	nucleus; Golgi membrane; membrane; integral component of membrane; Golgi apparatus; endomembrane system; plasma membrane;
Biological process	carbohydrate transport; epigenetic maintenance of chromatin in transcription-competent conformation; glucoside transport; hexose transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	55974
	19729
	ENSG00000169241
	ENSMUSG00000027953
	Q9BRV3
	Q9CXK4
NM_001122837; NM_001122839; NM_001287586; NM_001287587; NM_001287588;
	NM_001287589; NM_001287590; NM_001287591; NM_001287592; NM_018845
	NM_009057
NP_001116309; NP_001116311; NP_001274515; NP_001274516; NP_001274517;
	NP_001274518; NP_001274519; NP_001274520; NP_001274521; NP_061333
	NP_033083
	Wikidata
View/Edit Human	View/Edit Mouse

Sugar transporter SWEET1, also known as RAG1-activating protein 1 and stromal cell protein (SCP), is a membrane protein that in humans is encoded by the SLC50A1 gene. SWEET1 is the sole transporter from the SLC50 (SWEET) gene family present in the genomes of most animal species, with the exception of the nematode Caenorhabditis elegans, which has seven.

SWEET1 is a broadly-expressed glucose transporter. As the SWEET family has been identified relatively recently, the full range of its functions in animals is not yet clear. However, the bovine SLC50A1 homologue is associated with lactose concentration in milk, and the CiRGA homologue in the sea squirt Ciona intestinalis is essential for tissue differentiation during embryogenesis, especially the development of the notochord. SWEET genes are common in plant genomes, with around twenty paralogues functioning as both sucrose and hexose transporters, and are also associated with pathogen susceptibility.