Sodium-dependent multivitamin transporter

SLC5A6
Identifiers
Aliases	SLC5A6, SMVT, solute carrier family 5 member 6, NERIB
External IDs	OMIM: 604024; MGI: 2660847; HomoloGene: 23277; GeneCards: SLC5A6; OMA:SLC5A6 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	27,212,958 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	31,206,268 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right testis; ; left testis; ; right frontal lobe; ; placenta; ; right hemisphere of cerebellum; ; body of uterus; ; left uterine tube; ; right ovary; ; corpus epididymis;
	Top expressed in
	choroid plexus of fourth ventricle; ; morula; ; morula; ; yolk sac; ; Epithelium of choroid plexus; ; blastocyst; ; right kidney; ; Ileal epithelium; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	symporter activity; sodium-dependent multivitamin transmembrane transporter activity; transmembrane transporter activity;
Cellular component	vesicle membrane; integral component of membrane; brush border membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	ion transport; sodium ion transport; biotin transport; pantothenate transmembrane transport; transmembrane transport; biotin metabolic process; pantothenate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8884
	330064
	ENSG00000138074
	ENSMUSG00000006641
	Q9Y289
	Q5U4D8
	NM_021095
	NM_001177621; NM_001177622; NM_177870; NM_001360022
	NP_066918
	NP_001171092; NP_001171093; NP_808538; NP_001346951
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.

The SMVT is a transporter for pantothenic acid (vitamin B5) and biotin (vitamin B7) at the blood–brain barrier. It is also a transporter for lipoic acid and iodide. Transport of these nutrients is competitive and a surplus of a given nutrient may saturate the transporter and prevent the uptake of other nutrients.