Choline transporter

SLC5A7
Identifiers
Aliases	SLC5A7, CHT, CHT1, HMN7A, hCHT, Choline transporter, solute carrier family 5 member 7, CMS20
External IDs	OMIM: 608761; MGI: 1927126; HomoloGene: 32516; GeneCards: SLC5A7; OMA:SLC5A7 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	108,013,994 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	54,606,062 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; muscle layer of sigmoid colon; ; Epithelium of choroid plexus; ; putamen; ; urinary bladder; ; caudate nucleus; ; rectum; ; superior vestibular nucleus; ; smooth muscle tissue;
	Top expressed in
	lumbar subsegment of spinal cord; ; habenula; ; superior frontal gyrus; ; neural layer of retina; ; embryo; ; neural tube; ; cerebellar cortex; ; facial motor nucleus; ; central gray substance of midbrain; ; Gray matter of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	choline:sodium symporter activity; symporter activity; choline binding; choline transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane; soma; dendrite; integral component of plasma membrane; perikaryon; presynapse; axon; neuromuscular junction; cell junction; synapse;
Biological process	sodium ion transport; neurotransmitter biosynthetic process; ion transport; choline transport; transmembrane transport; acetylcholine biosynthetic process; neurotransmitter secretion; synaptic transmission, cholinergic; neuromuscular synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	60482
	63993
	ENSG00000115665
	ENSMUSG00000023945
	Q9GZV3; Q2T9H3
	Q8BGY9
	NM_001305005; NM_001305006; NM_001305007; NM_021815
	NM_022025
	NP_001291934; NP_001291935; NP_001291936; NP_068587; NP_001291936.1
	NP_071308
	Wikidata
View/Edit Human	View/Edit Mouse

The high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the SLC5A7 gene. It is a cell membrane transporter and carries choline into acetylcholine-synthesizing neurons.

Hemicholinium-3 is an inhibitor of the ChT and can be used to deplete acetylcholine stores, while coluracetam is an enhancer of the ChT and can increase cholinergic neurotransmission by enhancing acetylcholine synthesis.