Sodium/hydrogen exchanger 6

SLC9A6
Identifiers
Aliases	SLC9A6, MRSA, NHE6, solute carrier family 9 member A6, MRXSCH
External IDs	OMIM: 300231; MGI: 2443511; HomoloGene: 55971; GeneCards: SLC9A6; OMA:SLC9A6 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	136,047,269 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	55,709,590 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; middle temporal gyrus; ; Pons; ; pars compacta; ; postcentral gyrus; ; superior vestibular nucleus; ; orbitofrontal cortex; ; pars reticulata; ; superior frontal gyrus; ; entorhinal cortex;
	Top expressed in
	superior cervical ganglion; ; Region I of hippocampus proper; ; dorsomedial hypothalamic nucleus; ; substantia nigra; ; ventral tegmental area; ; otolith organ; ; central gray substance of midbrain; ; utricle; ; ciliary body; ; ventromedial nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	solute:proton antiporter activity; antiporter activity; potassium:proton antiporter activity; sodium:proton antiporter activity;
Cellular component	axon terminus; integral component of membrane; recycling endosome; endosome; late endosome; early endosome membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; axonal spine; plasma membrane; synapse; recycling endosome membrane; dendrite; early endosome; mitochondrion; endosome membrane; cytoplasmic vesicle;
Biological process	neuron projection morphogenesis; dendrite extension; sodium ion transport; proton transmembrane transport; synapse organization; cation transport; ion transport; brain-derived neurotrophic factor receptor signaling pathway; dendritic spine development; regulation of neurotrophin TRK receptor signaling pathway; axon extension; regulation of pH; potassium ion transmembrane transport; transmembrane transport; regulation of intracellular pH; sodium ion import across plasma membrane; anion transmembrane transport; sodium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	10479
	236794
	ENSG00000198689
	ENSMUSG00000060681
	Q92581
	n/a
NM_001042537; NM_001177651; NM_006359; NM_001330652; NM_001379110;
	NM_001400909; NM_001400910; NM_001400911; NM_001400912; NM_001400913
	NM_172780; NM_001358861
	NP_001036002; NP_001171122; NP_001317581; NP_006350; NP_001366039
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium/hydrogen exchanger 6 is an integral membrane protein that in humans is encoded by the SLC9A6 gene. It was originally thought to be a mitochondrial-targeted protein, but subsequent studies have localized it to the plasma membrane and recycling endosomes.

Loss of function causes Christianson syndrome.