Solute carrier organic anion transporter family member 1B1

SLCO1B1
Identifiers
Aliases	SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6, solute carrier organic anion transporter family member 1B1
External IDs	OMIM: 604843; MGI: 1351899; HomoloGene: 74575; GeneCards: SLCO1B1; OMA:SLCO1B1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	21,239,796 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	141,632,372 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; buccal mucosa cell; ; pancreatic ductal cell; ; gallbladder; ; renal cortex; ; cervix; ; canal of the cervix; ; mouth; ; haematopoietic system;
	Top expressed in
	left lobe of liver; ; embryo; ; sexually immature organism; ; medial head of gastrocnemius muscle; ; primary visual cortex; ; proximal tubule; ; jejunum; ; thoracic diaphragm; ; pancreas; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	transporter activity; sodium-independent organic anion transmembrane transporter activity; thyroid hormone transmembrane transporter activity; bile acid transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; integral component of plasma membrane; membrane;
Biological process	ion transport; bile acid and bile salt transport; organic anion transport; thyroid hormone transport; sodium-independent organic anion transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	10599
	28253
	ENSG00000134538
	ENSMUSG00000030236
	Q9Y6L6
	Q9JJL3
	NM_006446
	NM_020495; NM_178235
	NP_006437
	NP_065241
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin. Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.