SLU7

SLU7
Identifiers
Aliases	SLU7, 9G8, hSlu7, SLU7 homolog, splicing factor
External IDs	OMIM: 605974; MGI: 2385598; HomoloGene: 4690; GeneCards: SLU7; OMA:SLU7 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	160,421,711 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	43,338,808 bp
RNA expression pattern
	Top expressed in
	testicle; ; Achilles tendon; ; colon; ; superior frontal gyrus; ; sural nerve; ; prefrontal cortex; ; islet of Langerhans;
	Top expressed in
	saccule; ; otic vesicle; ; otic placode; ; genital tubercle; ; granulocyte; ; zygote; ; deep cerebellar nuclei; ; facial motor nucleus; ; vestibular sensory epithelium; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	pre-mRNA 3'-splice site binding; second spliceosomal transesterification activity; metal ion binding; protein binding; nucleic acid binding; zinc ion binding;
Cellular component	cytoplasm; nuclear speck; catalytic step 2 spliceosome; membrane; intracellular membrane-bounded organelle; small nuclear ribonucleoprotein complex; spliceosomal complex; nucleus; nucleoplasm; cytosol;
Biological process	cellular response to heat; RNA splicing, via transesterification reactions; mRNA processing; mRNA 3'-splice site recognition; RNA splicing; intracellular protein transport; alternative mRNA splicing, via spliceosome; RNA export from nucleus; mRNA splicing, via spliceosome; mRNA export from nucleus; mRNA 3'-end processing; termination of RNA polymerase II transcription;
	Sources:Amigo / QuickGO
Orthologs
	10569
	193116
	ENSG00000164609
	ENSMUSG00000020409
	O95391
	Q8BHJ9
	NM_006425
	NM_148673; NM_198936
NP_006416; NP_001351446; NP_001351447; NP_001351449; NP_001351450;
	NP_001351451; NP_001351452
	NP_683514; NP_945174
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene.

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions.