Cholinergic crisis

Cholinergic crisis
Other namesCholinergic toxicity, cholinergic poisoning, SLUDGE syndrome
SymptomsHypersalivation, lacrimation, increased urination and defecation, vomiting, sweating, constricted pupils, spasms
ComplicationsRespiratory failure, flaccid paralysis, death
CausesExcess synaptic levels of acetylcholine
Differential diagnosisMyasthenia gravis
MedicationAnticholinergics (atropine, diphenhydramine)

A cholinergic crisis is an over-stimulation at a neuromuscular junction due to an excess of acetylcholine, as a result of the inactivity of the acetylcholinesterase enzyme, which normally breaks down acetylcholine.

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