SLX4

SLX4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4M7C, 4UYI, 4ZOU
Identifiers
Aliases	SLX4, BTBD12, FANCP, MUS312, SLX4 structure-specific endonuclease subunit
External IDs	OMIM: 613278; MGI: 106299; HomoloGene: 23770; GeneCards: SLX4; OMA:SLX4 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	3,611,606 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	4,003,770 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; pancreatic ductal cell; ; gonad; ; granulocyte; ; testicle; ; right testis; ; left testis; ; stromal cell of endometrium; ; ventricular zone; ; tibialis anterior muscle;
	Top expressed in
	zygote; ; spermatocyte; ; genital tubercle; ; tail of embryo; ; spermatid; ; gastrula; ; neural layer of retina; ; secondary oocyte; ; seminiferous tubule; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; enzyme activator activity; endodeoxyribonuclease activity; crossover junction endodeoxyribonuclease activity; 5'-flap endonuclease activity; 3'-flap endonuclease activity;
Cellular component	ERCC4-ERCC1 complex; nucleoplasm; cell junction; Holliday junction resolvase complex; nucleus; telomere; cytosol; Slx1-Slx4 complex;
Biological process	nucleotide-excision repair; DNA recombination; positive regulation of t-circle formation; cellular response to DNA damage stimulus; DNA double-strand break processing involved in repair via single-strand annealing; DNA replication; response to intra-S DNA damage checkpoint signaling; positive regulation of catalytic activity; DNA repair; interstrand cross-link repair; resolution of meiotic recombination intermediates; double-strand break repair via homologous recombination; meiotic DNA double-strand break processing; telomeric D-loop disassembly; t-circle formation; negative regulation of telomere maintenance via telomere lengthening;
	Sources:Amigo / QuickGO
Orthologs
	84464
	52864
	ENSG00000188827
	ENSMUSG00000039738
	Q8IY92
	Q6P1D7
	NM_032444
	NM_177472
	NP_115820
NP_803423; NP_001389852; NP_001389853; NP_001389854; NP_001389855;
	NP_001389856; NP_001389857; NP_001389859; NP_001389860
	Wikidata
View/Edit Human	View/Edit Mouse

SLX4 (also known as BTBD12 and FANCP) is a protein involved in DNA repair, where it has important roles in the final steps of homologous recombination. Mutations in the gene are associated with the disease Fanconi anemia.

The version of SLX4 present in humans and other mammals acts as a sort of scaffold upon which other proteins form several different multiprotein complexes. The SLX1-SLX4 complex acts as a Holliday junction resolvase. As such, the complex cleaves the links between two homologous chromosomes that form during homologous recombination. This allows the two linked chromosomes to resolve into two unconnected double-strand DNA molecules. The SLX4 interacting protein interacts with SLX4 in the DNA repair process, specifically in interstrand crosslink repair. SLX4 also associates with RAD1, RAD10 and SAW1 in the single-strand annealing pathway of homologous recombination. The DNA repair function of SLX4 is involved in sensitivity to proton beam radiation.