Mothers against decapentaplegic homolog 6

SMAD6
Identifiers
Aliases	SMAD6, AOVD2, HsT17432, MADH6, MADH7, SMAD family member 6
External IDs	OMIM: 602931; MGI: 1336883; HomoloGene: 4079; GeneCards: SMAD6; OMA:SMAD6 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	66,782,849 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	63,929,341 bp
RNA expression pattern
	Top expressed in
	right lung; ; glomerulus; ; metanephric glomerulus; ; lower lobe of lung; ; right auricle of heart; ; upper lobe of lung; ; upper lobe of left lung; ; visceral pleura; ; Epithelium of choroid plexus; ; right lobe of thyroid gland;
	Top expressed in
	right lung; ; right lung lobe; ; molar; ; atrium; ; mesorchium; ; epithelium of stomach; ; choroid plexus of fourth ventricle; ; external carotid artery; ; left lung; ; gastrula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; R-SMAD binding; type I transforming growth factor beta receptor binding; co-SMAD binding; I-SMAD binding; DNA-binding transcription factor activity; chromatin binding; type I activin receptor binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; identical protein binding; ubiquitin protein ligase binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; transcription regulator complex; intracellular anatomical structure; nucleus; Golgi apparatus; cytosol; nuclear body; protein-containing complex;
Biological process	ureteric bud development; heart valve development; regulation of transcription, DNA-templated; ventricular septum development; zygotic specification of dorsal/ventral axis; negative regulation of SMAD protein complex assembly; response to laminar fluid shear stress; negative regulation of apoptotic process; negative regulation of transforming growth factor beta receptor signaling pathway; coronary vasculature development; BMP signaling pathway; transcription, DNA-templated; negative regulation of pathway-restricted SMAD protein phosphorylation; response to estrogen; negative regulation of BMP signaling pathway; aorta development; cell-substrate adhesion; immune response; transforming growth factor beta receptor signaling pathway; fat cell differentiation; negative regulation of cell population proliferation; positive regulation of pri-miRNA transcription by RNA polymerase II; outflow tract septum morphogenesis; mitral valve morphogenesis; pulmonary valve morphogenesis; negative regulation of ossification; aortic valve morphogenesis; negative regulation of osteoblast differentiation; response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	4091
	17130
	ENSG00000137834
	ENSMUSG00000036867
	O43541
	O35182
	NM_001142861; NM_005585
	NM_008542
	NP_005576
	NP_032568
	Wikidata
View/Edit Human	View/Edit Mouse

SMAD family member 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene.

SMAD6 is a protein that, as its name describes, is a homolog of the Drosophila gene "mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD6 is involved in cell signalling. It acts as a regulator of TGFβ family (such as bone morphogenetic proteins) activity by competing with SMAD4 and preventing the transcription of SMAD4's gene products. There are two known isoforms of this protein.