SMARCA1

SMARCA1
Identifiers
Aliases	SMARCA1, ISWI, NURF140, SNF2L, SNF2L1, SNF2LB, SNF2LT, SWI, SWI2, hSNF2L, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
External IDs	OMIM: 300012; MGI: 1935127; HomoloGene: 55711; GeneCards: SMARCA1; OMA:SMARCA1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	129,523,500 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	46,981,851 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; tibia; ; endothelial cell; ; ventricular zone; ; right adrenal cortex; ; left adrenal cortex; ; parietal pleura; ; seminal vesicula; ; stromal cell of endometrium; ; cartilage tissue;
	Top expressed in
	Gonadal ridge; ; vas deferens; ; fossa; ; efferent ductule; ; internal carotid artery; ; atrium; ; trigeminal ganglion; ; ureter; ; external carotid artery; ; ovary;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ATP-dependent DNA/DNA annealing activity; DNA binding; nucleotide binding; ATP-dependent activity, acting on DNA; helicase activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; protein binding; nucleic acid binding; nucleosome binding; hydrolase activity; ATP binding; transcription factor binding; ATPase activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	CERF complex; nucleus; nucleoplasm; intracellular membrane-bounded organelle; NURF complex;
Biological process	chromatin remodeling; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription, DNA-templated; brain development; neuron differentiation; chromatin organization; regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6594
	93761
	ENSG00000102038
	ENSMUSG00000031099
	P28370
	Q6PGB8
NM_001282874; NM_001282875; NM_003069; NM_139035; NM_001378261;
	NM_001378262; NM_001378263; NM_001378264
	NM_001290708; NM_053123; NM_001358618; NM_001358619
NP_001269803; NP_001269804; NP_003060; NP_001365190; NP_001365191;
	NP_001365192; NP_001365193
	NP_001277637; NP_444353; NP_001345547; NP_001345548
	Wikidata
View/Edit Human	View/Edit Mouse

Probable global transcription activator SNF2L1 is a protein that in humans is encoded by the SMARCA1 gene.

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Two transcript variants encoding different isoforms have been found for this gene.