SMARCA4

SMARCA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GRC, 2H60, 3UVD, 5DKD, 5EA1
Identifiers
Aliases	SMARCA4, BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b, CSS4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
External IDs	OMIM: 603254; MGI: 88192; HomoloGene: 135927; GeneCards: SMARCA4; OMA:SMARCA4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	11,065,395 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,615,526 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; tendon of biceps brachii; ; ventricular zone; ; amniotic fluid; ; epithelium of nasopharynx; ; sural nerve; ; middle temporal gyrus; ; primary visual cortex; ; endothelial cell; ; right hemisphere of cerebellum;
	Top expressed in
	Rostral migratory stream; ; otic vesicle; ; hand; ; ganglionic eminence; ; mandibular prominence; ; somite; ; tail of embryo; ; internal carotid artery; ; Gonadal ridge; ; maxillary prominence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; nucleotide binding; transcription coactivator activity; ATP-dependent activity, acting on DNA; RNA polymerase I core promoter sequence-specific DNA binding; helicase activity; transcription corepressor activity; protein N-terminus binding; histone binding; p53 binding; transcription factor binding; Tat protein binding; DNA polymerase binding; hydrolase activity, acting on acid anhydrides; ATPase activity; protein binding; androgen receptor binding; lysine-acetylated histone binding; nucleosomal DNA binding; hydrolase activity; ATP binding; RNA binding; DNA binding;
Cellular component	nBAF complex; membrane; SWI/SNF complex; nucleoplasm; npBAF complex; nucleolus; nucleus; extracellular space; protein-containing complex;
Biological process	positive regulation of glucose mediated signaling pathway; chromatin remodeling; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; negative regulation of androgen receptor signaling pathway; positive regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; nervous system development; positive regulation of transcription, DNA-templated; positive regulation of Wnt signaling pathway; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell growth; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation by host of viral transcription; neural retina development; positive regulation of transcription by RNA polymerase II; beta-catenin-TCF complex assembly; nucleosome disassembly; negative regulation of transcription, DNA-templated; chromatin organization; interleukin-7-mediated signaling pathway; RNA polymerase I preinitiation complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	6597
	20586
	ENSG00000127616
	ENSMUSG00000032187
	P51532; Q9HBD4
	Q3TKT4
NM_001128844; NM_001128845; NM_001128846; NM_001128847; NM_001128848;
	NM_001128849; NM_003072
	NM_001174078; NM_001174079; NM_011417; NM_001357764
NP_001122316; NP_001122317; NP_001122318; NP_001122319; NP_001122320;
	NP_001122321; NP_003063; NP_001361386; NP_001122321.1
	NP_001167549; NP_001167550; NP_035547; NP_001344693
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription activator BRG1 also known as ATP-dependent chromatin remodeler SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.