SMC2

SMC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4U4P
Identifiers
Aliases	SMC2, CAP-E, CAPE, SMC-2, SMC2L1, structural maintenance of chromosomes 2
External IDs	OMIM: 605576; MGI: 106067; HomoloGene: 4705; GeneCards: SMC2; OMA:SMC2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	104,141,419 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	52,488,260 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; testicle; ; ganglionic eminence; ; gonad; ; Achilles tendon; ; secondary oocyte; ; sperm; ; trabecular bone; ; bone marrow; ; bone marrow cells;
	Top expressed in
	tail of embryo; ; genital tubercle; ; primitive streak; ; abdominal wall; ; maxillary prominence; ; fetal liver hematopoietic progenitor cell; ; mandibular prominence; ; vas deferens; ; dermis; ; migratory enteric neural crest cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; protein heterodimerization activity; ATP binding; single-stranded DNA binding;
Cellular component	cytoplasm; cytosol; chromosome; nucleoplasm; condensin complex; nuclear chromosome; nucleolus; extracellular exosome; condensed chromosome; nucleus;
Biological process	kinetochore organization; meiotic chromosome condensation; chromosome organization; meiotic chromosome segregation; cell division; chromosome condensation; cell cycle; mitotic chromosome condensation;
	Sources:Amigo / QuickGO
Orthologs
	10592
	14211
	ENSG00000136824
	ENSMUSG00000028312
	O95347; Q05D74
	Q8CG48
	NM_001042550; NM_001042551; NM_001265602; NM_006444
	NM_001301412; NM_008017
	NP_001036015; NP_001036016; NP_001252531; NP_006435; NP_006435.2
	NP_001288341; NP_032043
	Wikidata
View/Edit Human	View/Edit Mouse

Structural maintenance of chromosomes protein 2 (SMC-2), also known as chromosome-associated protein E (CAP-E), is a protein that in humans is encoded by the SMC2 gene. SMC2 is part of the SMC protein family and is a core subunit of condensin I and II, large protein complexes involved in chromosome condensation, overall organization. Several studies have demonstrated the necessity of SMC2 for cell division and proliferation.