SMC5

SMC5
Identifiers
Aliases	SMC5, SMC5L1, structural maintenance of chromosomes 5
External IDs	OMIM: 609386; MGI: 2385088; HomoloGene: 41009; GeneCards: SMC5; OMA:SMC5 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	70,354,873 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	23,251,261 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Achilles tendon; ; left ovary; ; right ovary; ; ventricular zone; ; body of pancreas; ; epithelium of nasopharynx; ; rectum; ; mucosa of paranasal sinus; ; right lung;
	Top expressed in
	spermatid; ; seminiferous tubule; ; tail of embryo; ; spermatocyte; ; genital tubercle; ; neural layer of retina; ; lateral septal nucleus; ; maxillary prominence; ; ventricular zone; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; protein binding; ATP binding;
Cellular component	site of double-strand break; PML body; Smc5-Smc6 complex; chromosome; telomere; cell junction; interchromatin granule; nucleus; nucleoplasm; nuclear speck; sex chromosome;
Biological process	DNA recombination; positive regulation of maintenance of mitotic sister chromatid cohesion; cellular response to DNA damage stimulus; cell division; telomere maintenance via recombination; cellular senescence; positive regulation of chromosome segregation; double-strand break repair via homologous recombination; cell cycle; double-strand break repair via nonhomologous end joining; DNA repair; sister chromatid cohesion;
	Sources:Amigo / QuickGO
Orthologs
	23137
	226026
	ENSG00000198887
	ENSMUSG00000024943
	Q8IY18
	Q8CG46
	NM_015110
	NM_001252684; NM_001252685; NM_153808
	NP_055925
	NP_001239613; NP_001239614; NP_722503
	Wikidata
View/Edit Human	View/Edit Mouse

Structural maintenance of chromosomes protein 5 is a protein encoded by the SMC5 gene in human.

The structural maintenance of chromosomes' complex underlying mechanisms involved in the dynamics of chromatin dynamics is unknown, and discoveries are shedding light on the various functions. The SMC complex mediates long-distance interactions that enable higher-order chromatin folding in interphase. The SMC complex has an ATPase activity, a conserved kleisin, and regulatory subunits. SMC protein complexes are involved in DNA repair, transcriptional pathways, regulation of chromosome segregation, and immunity in Arabidopsis. In eukaryotes the structural maintenance chromosomes consists of cohesin (SMC1 AND SMC3), condensin (SMC2 and SMC4), and SMC5/6 complexes.