SMG5

SMG5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HWY
Identifiers
Aliases	SMG5, EST1B, LPTS-RP1, LPTSRP1, SMG-5, nonsense mediated mRNA decay factor, SMG5 nonsense mediated mRNA decay factor
External IDs	OMIM: 610962; MGI: 2447364; HomoloGene: 9095; GeneCards: SMG5; OMA:SMG5 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,282,825 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,269,645 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; anterior pituitary; ; right adrenal gland; ; granulocyte; ; right hemisphere of cerebellum; ; C1 segment; ; right adrenal cortex; ; left adrenal cortex; ; skin of leg;
	Top expressed in
	spermatocyte; ; spermatid; ; superior frontal gyrus; ; neural layer of retina; ; ventricular zone; ; lip; ; muscle of thigh; ; seminiferous tubule; ; dentate gyrus of hippocampal formation granule cell; ; tail of embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 2A binding; histone deacetylase binding; protein binding; telomeric DNA binding; ubiquitin protein ligase binding; ribonuclease activity; ribonucleoprotein complex binding; telomerase RNA binding;
Cellular component	cytoplasm; cytosol; nucleus; telomerase holoenzyme complex;
Biological process	regulation of dephosphorylation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; regulation of telomere maintenance; regulation of telomere maintenance via telomerase; regulation of RNA stability; RNA phosphodiester bond hydrolysis; telomere maintenance via telomerase;
	Sources:Amigo / QuickGO
Orthologs
	23381
	229512
	ENSG00000198952
	ENSMUSG00000001415
	Q9UPR3
	Q6ZPY2
	NM_015327; NM_001323614; NM_001323615; NM_001323616; NM_001323617
	NM_173188; NM_178246
	NP_001310543; NP_001310544; NP_001310545; NP_001310546; NP_056142
	NP_839977
	Wikidata
View/Edit Human	View/Edit Mouse

Protein SMG5 is a protein that in humans is encoded by the SMG5 gene. This protein contains a PIN domain that appears to have mutated the residues in the active site.