SMIM20

SMIM20
Identifiers
Aliases	SMIM20, C4orf52, small integral membrane protein 20, MITRAC7, PNX
External IDs	OMIM: 617465; MGI: 1913528; HomoloGene: 82612; GeneCards: SMIM20; OMA:SMIM20 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	25,929,813 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	53,435,882 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; deltoid muscle; ; muscle of leg; ; gastrocnemius muscle; ; tibialis anterior muscle; ; Achilles tendon; ; muscle of thigh; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; biceps brachii;
	Top expressed in
	right kidney; ; muscle of thigh; ; soleus muscle; ; otolith organ; ; knee joint; ; utricle; ; gastrocnemius muscle; ; masseter muscle; ; quadriceps femoris muscle; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	membrane; integral component of membrane; mitochondrion; mitochondrial inner membrane;
Biological process	mitochondrial cytochrome c oxidase assembly;
	Sources:Amigo / QuickGO
Orthologs
	389203
	66278
	ENSG00000250317
	ENSMUSG00000061461
	Q8N5G0
	D3Z7Q2
	NM_001145432; NM_001394130
	NM_001145433
	NP_001138904
	NP_001138905
	Wikidata
View/Edit Human	View/Edit Mouse

Small integral membrane protein 20 (SMIM20) is a protein that in humans is encoded by the SMIM20 gene. SMIM20 acts as a prohormone to the peptide hormone phoenixin (PNX) which was discovered for the first time in 2013 in rodent sensory ganglia. Two alternate cleavage sites within SMIM20 results in two different phoenixin products, Phoenixin-14 (PNX-14) and Phoenixin-20 (PNX-20).

In the study of the evolution of nervous systems, SMIM20 together with NUCB2 have been found to have deep homology across all lineages that preceded creatures with central nervous systems, bilaterians, cnidarians, ctenophores, and sponges as well as in choanoflagellates.