SMTN

SMTN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D87
Identifiers
Aliases	SMTN, smoothelin
External IDs	OMIM: 602127; MGI: 1354727; HomoloGene: 8482; GeneCards: SMTN; OMA:SMTN - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,104,757 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,490,612 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; popliteal artery; ; tibial arteries; ; muscle layer of sigmoid colon; ; body of uterus; ; apex of heart; ; left uterine tube; ; Descending thoracic aorta; ; ascending aorta; ; right coronary artery;
	Top expressed in
	tunica media of zone of aorta; ; ascending aorta; ; uterus; ; lip; ; aortic valve; ; temporal muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; structural constituent of muscle;
Cellular component	cytoplasm; cytoskeleton; actin cytoskeleton; microtubule organizing center; filamentous actin; nucleoplasm;
Biological process	smooth muscle contraction; muscle organ development; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	6525
	29856
	ENSG00000183963
	ENSMUSG00000020439
	P53814
	Q921U8
	NM_001207017; NM_001207018; NM_006932; NM_134269; NM_134270
	NM_001159284; NM_001284427; NM_001284428; NM_001284429; NM_013870
NP_001193946; NP_001193947; NP_008863; NP_599031; NP_599032;
	NP_001369567; NP_001369568; NP_001369569; NP_001369570; NP_001369571; NP_001369572; NP_001369573; NP_001369574; NP_001369575; NP_001369576; NP_001369577
	NP_001152756; NP_001271356; NP_001271357; NP_001271358; NP_038898
	Wikidata
View/Edit Human	View/Edit Mouse

Smoothelin is a protein that in humans is encoded by the SMTN gene.

This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.