SMUG1

SMUG1
Identifiers
Aliases	SMUG1, FDG, HMUDG, UNG3, single-strand-selective monofunctional uracil-DNA glycosylase 1
External IDs	OMIM: 607753; MGI: 1918976; HomoloGene: 8629; GeneCards: SMUG1; OMA:SMUG1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	103,075,519 bp
RNA expression pattern
	n/a
	Top expressed in
	secondary oocyte; ; primary oocyte; ; neural layer of retina; ; tail of embryo; ; zygote; ; otic vesicle; ; hair follicle; ; retinal pigment epithelium; ; epithelium of urethra; ; otolith organ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; uracil DNA N-glycosylase activity; DNA N-glycosylase activity; protein binding; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity; hydrolase activity; single-strand selective uracil DNA N-glycosylase activity;
Cellular component	nucleolus; nucleus; nucleoplasm;
Biological process	depyrimidination; cellular response to DNA damage stimulus; base-excision repair; DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	23583
	71726
	ENSG00000123415
	ENSMUSG00000036061
	Q53HV7
	Q6P5C5
NM_001243787; NM_001243788; NM_001243789; NM_001243790; NM_001243791;
	NM_014311
	NM_027885
NP_001230716; NP_001230717; NP_001230718; NP_001230719; NP_001230720;
	NP_055126; NP_001338166; NP_001338167; NP_001338168; NP_001338169; NP_001338170; NP_001338171; NP_001338172; NP_001338173; NP_001338174; NP_001338175; NP_001338176; NP_001338177; NP_001338178; NP_001338179; NP_001338180; NP_001338181; NP_001338182; NP_001338183; NP_001338184; NP_001338185; NP_001338186; NP_001338187; NP_001338188; NP_001338189; NP_001338190; NP_001338191
	NP_082161
	Wikidata
View/Edit Human	View/Edit Mouse

Single-strand selective monofunctional uracil DNA glycosylase is an enzyme that in humans is encoded by the SMUG1 gene. SMUG1 is a glycosylase that removes uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair.