SMURF1

SMURF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LAZ, 2LB0, 2LB1, 2LTX, 3PYC
Identifiers
Aliases	SMURF1, SMAD specific E3 ubiquitin protein ligase 1
External IDs	OMIM: 605568; MGI: 1923038; HomoloGene: 10712; GeneCards: SMURF1; OMA:SMURF1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	99,144,108 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	144,902,657 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; sural nerve; ; islet of Langerhans; ; left ovary; ; skin of leg; ; gastric mucosa; ; skin of abdomen; ; right lung; ; left coronary artery;
	Top expressed in
	gastrula; ; spermatocyte; ; zygote; ; secondary oocyte; ; tail of embryo; ; seminiferous tubule; ; spermatid; ; submandibular gland; ; otolith organ; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	R-SMAD binding; I-SMAD binding; activin binding; protein binding; phospholipid binding; transferase activity; ubiquitin-protein transferase activity; ubiquitin protein ligase activity;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; nucleoplasm; axon; soma; mitochondrion; extracellular exosome;
Biological process	cell differentiation; engulfment of target by autophagosome; ectoderm development; protein polyubiquitination; BMP signaling pathway; receptor catabolic process; ubiquitin-dependent SMAD protein catabolic process; negative regulation of ossification; protein localization to cell surface; protein targeting to vacuole involved in autophagy; positive regulation of ubiquitin-dependent protein catabolic process; protein ubiquitination; protein export from nucleus; positive regulation of dendrite extension; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway; Wnt signaling pathway, planar cell polarity pathway; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; substrate localization to autophagosome; ubiquitin-dependent protein catabolic process; negative regulation of BMP signaling pathway; protein localization to plasma membrane; positive regulation of protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	57154
	75788
	ENSG00000284126; ENSG00000198742
	ENSMUSG00000038780
	Q9HCE7
	Q9CUN6
	NM_001199847; NM_020429; NM_181349
	NM_001038627; NM_029438
	NP_001186776; NP_065162; NP_851994
	NP_001033716; NP_083714
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene. The SMURF1 Gene encodes a protein with a size of 757 amino acids and the molecular mass of this protein is 86114 Da.