SNAI2

SNAI2
Identifiers
Aliases	SNAI2, SLUG, SLUGH1, SNAIL2, WS2D, snail family transcriptional repressor 2, SLUGH
External IDs	OMIM: 602150; MGI: 1096393; HomoloGene: 31127; GeneCards: SNAI2; OMA:SNAI2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	48,921,740 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	14,527,249 bp
RNA expression pattern
	Top expressed in
	tibia; ; cartilage tissue; ; stromal cell of endometrium; ; skin of thigh; ; skin of arm; ; skin of hip; ; periodontal fiber; ; mucosa of paranasal sinus; ; tail of epididymis; ; seminal vesicula;
	Top expressed in
	condyle; ; fossa; ; migratory enteric neural crest cell; ; conjunctival fornix; ; endothelial cell of lymphatic vessel; ; hair follicle; ; vas deferens; ; calvaria; ; maxillary prominence; ; body of femur;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; metal ion binding; protein binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin binding; DNA-binding transcription factor activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; E-box binding;
Cellular component	cytoplasm; nucleus; nucleoplasm;
Biological process	Notch signaling pathway; negative regulation of vitamin D receptor signaling pathway; regulation of transcription, DNA-templated; neural crest cell development; negative regulation of keratinocyte proliferation; regulation of bicellular tight junction assembly; positive regulation of cell migration; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; transcription, DNA-templated; cellular response to epidermal growth factor stimulus; negative regulation of vitamin D biosynthetic process; regulation of chemokine production; multicellular organism development; negative regulation of chondrocyte differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; regulation of osteoblast differentiation; osteoblast differentiation; canonical Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cell adhesion mediated by integrin; negative regulation of anoikis; negative regulation of transcription by RNA polymerase II; epithelial to mesenchymal transition; epithelial to mesenchymal transition involved in endocardial cushion formation; cell migration involved in endocardial cushion formation; hearing; desmosome disassembly; pigmentation; epithelium development; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; aortic valve morphogenesis; negative regulation of cell adhesion involved in substrate-bound cell migration; response to radiation; cell migration; positive regulation of histone acetylation; negative regulation of apoptotic process; positive regulation of fat cell differentiation; white fat cell differentiation; roof of mouth development; cartilage morphogenesis; regulation of branching involved in salivary gland morphogenesis; cellular response to ionizing radiation; negative regulation of stem cell proliferation; Notch signaling involved in heart development;
	Sources:Amigo / QuickGO
Orthologs
	6591
	20583
	ENSG00000019549
	ENSMUSG00000022676
	O43623
	P97469
	NM_003068
	NM_011415
	NP_003059
	NP_035545
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein SNAI2 (also called SLUG) is a transcription factor that in humans is encoded by the SNAI2 gene. It promotes epithelial to mesenchymal transition, differentiation (e.g. in gastrulation), and migration of cells.