Gamma-synuclein

SNCG
Identifiers
Aliases	SNCG, BCSG1, SR, synuclein gamma
External IDs	OMIM: 602998; MGI: 1298397; HomoloGene: 2322; GeneCards: SNCG; OMA:SNCG - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	86,963,258 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	34,096,746 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; popliteal artery; ; tibial arteries; ; right frontal lobe; ; Amygdala; ; anterior cingulate cortex; ; left coronary artery; ; right coronary artery; ; lateral nuclear group of thalamus;
	Top expressed in
	facial motor nucleus; ; white adipose tissue; ; lactiferous gland; ; spinal ganglia; ; superior cervical ganglion; ; anterior horn of spinal cord; ; neural layer of retina; ; sciatic nerve; ; trigeminal ganglion; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; microtubule organizing center; perinuclear region of cytoplasm; axon; soma; spindle; extracellular exosome; cytoskeleton;
Biological process	protein secretion; adult locomotory behavior; regulation of dopamine secretion; synapse organization; regulation of neurotransmitter secretion; chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	6623
	20618
	ENSG00000173267
	ENSMUSG00000023064
	O76070
	Q9Z0F7
	NM_003087; NM_001330120
	NM_011430
	NP_001317049; NP_003078
	NP_035560
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-synuclein is a protein that in humans is encoded by the SNCG gene.

Synuclein-gamma is a member of the synuclein family of proteins, which are believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development. Gamma-synuclein is a synuclein protein found primarily in the peripheral nervous system (in primary sensory neurons, sympathetic neurons, and motor neurons) and retina. It is also detected in the brain, ovarian tumors, and in the olfactory epithelium. Gamma-synuclein is the least conserved of the synuclein proteins.

Gamma-Synucleins expression in breast tumors is a marker for tumor progression as mammalian gamma-synuclein was first identified as breast cancer-specific gene 1 (BCSG1). A change in the expression of gamma-synuclein has been observed in the retina of patients with Alzheimer's disease. The normal cellular function of gamma-synuclein remains unknown.