SNF8

SNF8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZME, 3CUQ
Identifiers
Aliases	SNF8, Dot3, EAP30, VPS22, ESCRT-II complex subunit, SNF8 subunit of ESCRT-II
External IDs	OMIM: 610904; MGI: 1343161; HomoloGene: 5239; GeneCards: SNF8; OMA:SNF8 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	48,944,842 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,938,256 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; mucosa of transverse colon; ; gastric mucosa; ; stromal cell of endometrium; ; left coronary artery; ; ganglionic eminence; ; right auricle of heart; ; right adrenal gland; ; popliteal artery; ; tibial arteries;
	Top expressed in
	embryo; ; yolk sac; ; morula; ; dentate gyrus of hippocampal formation granule cell; ; epiblast; ; blastocyst; ; right kidney; ; superior frontal gyrus; ; facial motor nucleus; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein N-terminus binding; transcription factor binding; protein C-terminus binding; channel regulator activity; protein binding;
Cellular component	cytoplasm; recycling endosome; cytosol; endosome; membrane; late endosome membrane; transcription regulator complex; plasma membrane; nucleoplasm; perinuclear region of cytoplasm; endosome membrane; extracellular exosome; nucleus; ESCRT II complex;
Biological process	regulation of transcription, DNA-templated; positive regulation of protein catabolic process; multivesicular body sorting pathway; regulation of transcription by RNA polymerase II; multivesicular body assembly; regulation of multivesicular body size involved in endosome transport; transcription, DNA-templated; endosomal transport; regulation of protein complex stability; positive regulation of gene expression; early endosome to late endosome transport; endocytic recycling; regulation of protein catabolic process; protein transport; regulation of MAP kinase activity; positive regulation of exosomal secretion; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; macroautophagy; regulation of molecular function; transport;
	Sources:Amigo / QuickGO
Orthologs
	11267
	27681
	ENSG00000159210
	ENSMUSG00000006058
	Q96H20
	Q9CZ28
	NM_007241; NM_001317192; NM_001317193; NM_001317194
	NM_033568; NM_001356362
	NP_001304121; NP_001304122; NP_001304123; NP_009172
	NP_291046; NP_001343291
	Wikidata
View/Edit Human	View/Edit Mouse

Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene. It is a part of ESCRT-II complex.