SNRPB2

SNRPB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A9N
Identifiers
Aliases	SNRPB2, Msl1, U2B'', small nuclear ribonucleoprotein polypeptide B2
External IDs	OMIM: 603520; MGI: 104805; HomoloGene: 37728; GeneCards: SNRPB2; OMA:SNRPB2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	16,742,564 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	142,914,773 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ganglionic eminence; ; Achilles tendon; ; monocyte; ; epithelium of nasopharynx; ; skin of hip; ; appendix; ; islet of Langerhans; ; superficial temporal artery;
	Top expressed in
	medial ganglionic eminence; ; abdominal wall; ; primitive streak; ; maxillary prominence; ; mandibular prominence; ; dermis; ; otic placode; ; ventricular zone; ; cumulus cell; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; snRNA stem-loop binding; protein binding; RNA binding; snRNP binding; U1 snRNA binding;
Cellular component	catalytic step 2 spliceosome; spliceosomal complex; U2 snRNP; small nuclear ribonucleoprotein complex; fibrillar center; nucleoplasm; nuclear speck; U1 snRNP; U2-type catalytic step 2 spliceosome; nucleus; U2-type precatalytic spliceosome;
Biological process	mRNA processing; RNA splicing; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	6629
	20639
	ENSG00000125870
	ENSMUSG00000008333
	P08579
	Q9CQI7
	NM_198220; NM_003092
	NM_021335
	NP_003083; NP_937863
	NP_067310
	Wikidata
View/Edit Human	View/Edit Mouse

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.