SNX5

SNX5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SYS
Identifiers
Aliases	SNX5, sorting nexin 5
External IDs	OMIM: 605937; MGI: 1916428; HomoloGene: 40944; GeneCards: SNX5; OMA:SNX5 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	17,968,980 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	144,112,826 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; ventricular zone; ; Achilles tendon; ; rectum; ; gonad; ; spleen; ; corpus epididymis; ; secondary oocyte; ; left ovary;
	Top expressed in
	stroma of bone marrow; ; tail of embryo; ; abdominal wall; ; epiblast; ; Gonadal ridge; ; mandibular prominence; ; dermis; ; efferent ductule; ; migratory enteric neural crest cell; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	dynactin binding; protein binding; phosphatidylinositol binding; protein heterodimerization activity; lipid binding; cadherin binding; phosphatidylinositol-5-phosphate binding; D1 dopamine receptor binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding;
Cellular component	cytoplasm; endosome; cell projection; early endosome membrane; retromer, tubulation complex; membrane; ruffle; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; extrinsic component of endosome membrane; tubular endosome; retromer complex; early endosome; phagocytic cup; cytoplasmic vesicle membrane; macropinocytic cup; cytoplasmic vesicle; cytosol; brush border; intracellular anatomical structure;
Biological process	endocytosis; vesicle organization; retrograde transport, endosome to Golgi; protein transport; pinocytosis; intracellular protein transport; regulation of macroautophagy; epidermal growth factor catabolic process; positive regulation of renal sodium excretion; negative regulation of blood pressure;
	Sources:Amigo / QuickGO
Orthologs
	27131
	69178
	ENSG00000089006
	ENSMUSG00000027423
	Q9Y5X3; Q5QPE4
	Q9D8U8
	NM_152227; NM_001282454; NM_014426
	NM_001199188; NM_024225
	NP_001269383; NP_055241; NP_689413
	NP_001186117; NP_077187
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex, which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.