SNX9

SNX9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RAI, 2RAJ, 2RAK, 3DYT, 3DYU, 3LGE
Identifiers
Aliases	SNX9, SDP1, SH3PX1, SH3PXD3A, WISP, sorting nexin 9
External IDs	OMIM: 605952; MGI: 1913866; HomoloGene: 49454; GeneCards: SNX9; OMA:SNX9 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	157,945,077 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	5,982,229 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; mucosa of ileum; ; superficial temporal artery; ; Achilles tendon; ; decidua; ; right coronary artery; ; tendon of biceps brachii; ; tail of epididymis; ; synovial membrane; ; tibial arteries;
	Top expressed in
	Ileal epithelium; ; zygote; ; secondary oocyte; ; primary oocyte; ; choroid plexus of fourth ventricle; ; jejunum; ; lactiferous gland; ; duodenum; ; right kidney; ; calvaria;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; Arp2/3 complex binding; 1-phosphatidylinositol binding; protein binding; phosphatidylinositol binding; ubiquitin protein ligase binding; lipid binding; cadherin binding; identical protein binding;
Cellular component	cytoplasm; Golgi apparatus; cell projection; membrane; ruffle; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; trans-Golgi network; extracellular exosome; cytoplasmic vesicle membrane; clathrin-coated vesicle; cytosol; cytoplasmic vesicle; cuticular plate;
Biological process	endocytosis; cleavage furrow formation; mitotic cytokinesis; positive regulation of membrane protein ectodomain proteolysis; receptor-mediated endocytosis; plasma membrane tubulation; cell division; endosomal transport; positive regulation of GTPase activity; positive regulation of protein oligomerization; protein transport; lipid tube assembly; cell cycle; intracellular protein transport; positive regulation of protein kinase activity; membrane organization; mitotic cell cycle; transport; positive regulation of actin filament polymerization;
	Sources:Amigo / QuickGO
Orthologs
	51429
	66616
	ENSG00000130340
	ENSMUSG00000002365
	Q9Y5X1
	Q91VH2
	NM_016224
	NM_025664
	NP_057308
	NP_079940
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.