Suppressor of cytokine signaling 1

SOCS1
Identifiers
Aliases	SOCS1, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, suppressor of cytokine signaling 1, TIP-3, AISIMD
External IDs	OMIM: 603597; MGI: 1354910; HomoloGene: 2776; GeneCards: SOCS1; OMA:SOCS1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	11,256,204 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	10,603,400 bp
RNA expression pattern
	Top expressed in
	beta cell; ; sperm; ; canal of the cervix; ; testicle; ; spleen; ; appendix; ; superficial temporal artery; ; granulocyte; ; lymph node; ; ectocervix;
	Top expressed in
	thymus; ; granulocyte; ; submandibular gland; ; mesenteric lymph nodes; ; zygote; ; embryo; ; morula; ; secondary oocyte; ; bone marrow; ; vastus lateralis muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	insulin-like growth factor receptor binding; protein kinase inhibitor activity; protein binding; protein kinase binding; kinase inhibitor activity; 1-phosphatidylinositol-3-kinase regulator activity;
Cellular component	cytoplasm; cytosol; cytoplasmic vesicle; nucleus; nucleoplasm; cytoplasmic ribonucleoprotein granule; phosphatidylinositol 3-kinase complex;
Biological process	intracellular signal transduction; regulation of interferon-gamma-mediated signaling pathway; protein ubiquitination; regulation of growth; negative regulation of signal transduction; negative regulation of protein kinase activity; negative regulation of receptor signaling pathway via JAK-STAT; positive regulation of regulatory T cell differentiation; interleukin-7-mediated signaling pathway; regulation of protein phosphorylation; cytokine-mediated signaling pathway; negative regulation of tyrosine phosphorylation of STAT protein; positive regulation of CD4-positive, alpha-beta T cell differentiation; negative regulation of CD8-positive, alpha-beta T cell differentiation; negative regulation of insulin receptor signaling pathway; receptor signaling pathway via JAK-STAT; regulation of activation of Janus kinase activity; negative regulation of kinase activity; regulation of tyrosine phosphorylation of STAT protein; regulation of phosphatidylinositol 3-kinase activity; fat cell differentiation; regulation of receptor signaling pathway via JAK-STAT; phosphatidylinositol phosphate biosynthetic process; cellular response to amino acid stimulus;
	Sources:Amigo / QuickGO
Orthologs
	8651
	12703
	ENSG00000185338
	ENSMUSG00000038037
	O15524
	O35716
	NM_003745
	NM_001271603; NM_009896
	NP_003736
	NP_001258532; NP_034026
	Wikidata
View/Edit Human	View/Edit Mouse

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene. SOCS1 orthologs have been identified in several mammals for which complete genome data are available.