SOCS2

SOCS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C9W, 4JGH, 5BO4
Identifiers
Aliases	SOCS2, CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2, suppressor of cytokine signaling 2
External IDs	OMIM: 605117; MGI: 1201787; HomoloGene: 2880; GeneCards: SOCS2; OMA:SOCS2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	93,583,487 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	95,253,042 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; canal of the cervix; ; vena cava; ; body of uterus; ; myometrium; ; seminal vesicula; ; Epithelium of choroid plexus; ; ectocervix; ; prostate; ; pituitary gland;
	Top expressed in
	cumulus cell; ; Ileal epithelium; ; olfactory epithelium; ; vestibular membrane of cochlear duct; ; left lung lobe; ; vestibular sensory epithelium; ; stria vascularis; ; Gonadal ridge; ; right lung; ; interventricular septum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	insulin-like growth factor receptor binding; protein kinase inhibitor activity; JAK pathway signal transduction adaptor activity; protein binding; growth hormone receptor binding; 1-phosphatidylinositol-3-kinase regulator activity;
Cellular component	cytoplasm; cytosol; phosphatidylinositol 3-kinase complex;
Biological process	receptor signaling pathway via JAK-STAT; response to estradiol; intracellular signal transduction; negative regulation of protein kinase activity; cytokine-mediated signaling pathway; negative regulation of apoptotic process; negative regulation of insulin receptor signaling pathway; cellular response to hormone stimulus; growth hormone receptor signaling pathway; regulation of signal transduction; regulation of cell growth; protein ubiquitination; regulation of growth; negative regulation of signal transduction; negative regulation of receptor signaling pathway via JAK-STAT; positive regulation of signal transduction; lactation; regulation of multicellular organism growth; negative regulation of multicellular organism growth; post-translational protein modification; positive regulation of neuron differentiation; mammary gland alveolus development; interleukin-7-mediated signaling pathway; regulation of phosphatidylinositol 3-kinase activity; phosphatidylinositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	8835
	216233
	ENSG00000120833
	ENSMUSG00000020027
	O14508
	O35717
NM_001270467; NM_001270468; NM_001270469; NM_001270470; NM_001270471;
	NM_003877
	NM_001168655; NM_001168656; NM_001168657; NM_007706
NP_001257396; NP_001257397; NP_001257398; NP_001257399; NP_001257400;
	NP_003868
	NP_001162126; NP_001162127; NP_001162128; NP_031732
	Wikidata
View/Edit Human	View/Edit Mouse

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.