SOCS3

SOCS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BBU, 2HMH, 2JZ3, 4GL9
Identifiers
Aliases	SOCS3, ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3, suppressor of cytokine signaling 3
External IDs	OMIM: 604176; MGI: 1201791; HomoloGene: 2941; GeneCards: SOCS3; OMA:SOCS3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	78,360,077 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	117,860,873 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; left uterine tube; ; vena cava; ; gallbladder; ; saphenous vein; ; pericardium; ; seminal vesicula; ; upper lobe of left lung; ; lower lobe of lung; ; lactiferous duct;
	Top expressed in
	stroma of bone marrow; ; lumbar spinal ganglion; ; granulocyte; ; decidua; ; internal carotid artery; ; mesenteric lymph nodes; ; gastrula; ; islet of Langerhans; ; external carotid artery; ; ciliary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase inhibitor activity; protein binding; phosphotyrosine residue binding; 1-phosphatidylinositol-3-kinase regulator activity;
Cellular component	cytosol; cytoplasm; phosphatidylinositol 3-kinase complex; intracellular anatomical structure;
Biological process	regulation of protein phosphorylation; trophoblast giant cell differentiation; intracellular signal transduction; spongiotrophoblast differentiation; placenta blood vessel development; negative regulation of apoptotic process; negative regulation of insulin receptor signaling pathway; regulation of interferon-gamma-mediated signaling pathway; branching involved in labyrinthine layer morphogenesis; protein ubiquitination; positive regulation of cell differentiation; regulation of cell differentiation; regulation of growth; negative regulation of signal transduction; negative regulation of inflammatory response; negative regulation of protein kinase activity; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of tyrosine phosphorylation of STAT protein; post-translational protein modification; cellular response to leukemia inhibitory factor; positive regulation of tyrosine phosphorylation of STAT protein; receptor signaling pathway via JAK-STAT; cytokine-mediated signaling pathway; interleukin-6-mediated signaling pathway; regulation of phosphatidylinositol 3-kinase activity; phosphatidylinositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9021
	12702
	ENSG00000184557
	ENSMUSG00000053113
	O14543; Q6FI39
	O35718
	NM_003955; NM_001378932; NM_001378933
	NM_007707
	NP_003946; NP_001365861; NP_001365862; NP_003946.3
	NP_031733
	Wikidata
View/Edit Human	View/Edit Mouse

Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.

SOCS3 is a conserved gene, found in across the animal kingdom, including Drosophila, chickens, and crocodiles.