SOD2

SOD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AP5, 1AP6, 1EM1, 1JA8, 1LUV, 1LUW, 1MSD, 1N0J, 1N0N, 1PL4, 1PM9, 1QNM, 1SZX, 1VAR, 1XDC, 1XIL, 1ZSP, 1ZTE, 1ZUQ, 2ADP, 2ADQ, 2GDS, 2P4K, 2QKA, 2QKC, 3C3S, 3C3T
Identifiers
Aliases	SOD2, IPOB, MNSOD, MVCD6, IPO-B, Mn-SOD, superoxide dismutase 2, mitochondrial, superoxide dismutase 2, GClnc1
External IDs	OMIM: 147460; MGI: 98352; HomoloGene: 530; GeneCards: SOD2; OMA:SOD2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	159,762,529 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	13,258,950 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; beta cell; ; Achilles tendon; ; blood; ; cartilage tissue; ; gastric mucosa; ; monocyte; ; gallbladder; ; epithelium of colon; ; left adrenal gland;
	Top expressed in
	right ventricle; ; right kidney; ; atrioventricular valve; ; myocardium of ventricle; ; cardiac muscles; ; Epithelium of choroid plexus; ; facial motor nucleus; ; endocardial cushion; ; intercostal muscle; ; digastric muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	superoxide dismutase activity; manganese ion binding; metal ion binding; identical protein binding; oxidoreductase activity;
Cellular component	mitochondrion; extracellular exosome; mitochondrial matrix;
Biological process	negative regulation of neuron apoptotic process; response to superoxide; regulation of transcription by RNA polymerase II; removal of superoxide radicals; acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure; regulation of blood pressure; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; protein homotetramerization; oxygen homeostasis; release of cytochrome c from mitochondria; superoxide metabolic process; negative regulation of cell population proliferation; positive regulation of cell migration; mitochondrion organization; cellular response to oxidative stress; interleukin-12-mediated signaling pathway; ageing; negative regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular associated smooth muscle cell apoptotic process; positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching;
	Sources:Amigo / QuickGO
Orthologs
	6648
	20656
	ENSG00000112096
	ENSMUSG00000006818
	P04179
	P09671
NM_000636; NM_001024465; NM_001024466; NM_001322814; NM_001322815;
	NM_001322816; NM_001322817; NM_001322819; NM_001322820
	NM_013671
NP_000627; NP_001019636; NP_001019637; NP_001309743; NP_001309744;
	NP_001309745; NP_001309746; NP_001309748; NP_001309749
	NP_038699
	Wikidata
View/Edit Human	View/Edit Mouse

Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6. A related pseudogene has been identified on chromosome 1. Alternative splicing of this gene results in multiple transcript variants. This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer.