SORBS1

SORBS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DL3, 2ECZ, 2LJ0, 2MOX, 2O2W, 2O31, 2O9S, 2O9V, 4LN2, 4LNP
Identifiers
Aliases	SORBS1, CAP, FLAF2, R85FL, SH3D5, SH3P12, SORB1, sorbin and SH3 domain containing 1
External IDs	OMIM: 605264; MGI: 700014; HomoloGene: 83252; GeneCards: SORBS1; OMA:SORBS1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	95,561,414 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	40,513,779 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; myocardium of left ventricle; ; tail of epididymis; ; cardiac muscle tissue of right atrium; ; Descending thoracic aorta; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; right ventricle;
	Top expressed in
	Rostral migratory stream; ; tunica adventitia of aorta; ; subcutaneous adipose tissue; ; white adipose tissue; ; intercostal muscle; ; brown adipose tissue; ; myocardium of ventricle; ; paraventricular nucleus of hypothalamus; ; globus pallidus; ; tunica media of zone of aorta;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	insulin receptor binding; cytoskeletal protein binding; protein binding; actin binding;
Cellular component	cytosol; centrosome; membrane; focal adhesion; nuclear matrix; adherens junction; plasma membrane; stress fiber; cell junction; zonula adherens; membrane raft; cytoskeleton; nucleus; insulin receptor complex; cytoplasm;
Biological process	positive regulation of glucose import; positive regulation of glycogen biosynthetic process; muscle contraction; positive regulation of lipid biosynthetic process; actin filament organization; stress fiber assembly; focal adhesion assembly; cellular response to insulin stimulus; cell-matrix adhesion; positive regulation of signal transduction; positive regulation of protein localization to plasma membrane; insulin receptor signaling pathway; positive regulation of insulin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10580
	20411
	ENSG00000095637
	ENSMUSG00000025006
	Q9BX66
	Q62417
NM_001034954; NM_001034955; NM_001034956; NM_001034957; NM_001290294;
	NM_001290295; NM_001290296; NM_001290297; NM_001290298; NM_006434; NM_015385; NM_024991; NM_001377197; NM_001377198; NM_001377199; NM_001377200; NM_001377201; NM_001377202; NM_001377203; NM_001377204; NM_001377205; NM_001377206; NM_001377207; NM_001377208; NM_001377209; NM_001384447; NM_001384448; NM_001384449; NM_001384450; NM_001384451; NM_001384452; NM_001384453; NM_001384454; NM_001384455; NM_001384456; NM_001384457; NM_001384458; NM_001384459; NM_001384460; NM_001384461; NM_001384462; NM_001384463; NM_001384464; NM_001384465
	NM_001034962; NM_001034963; NM_001034964; NM_009166; NM_178362
NP_001030126; NP_001030127; NP_001030128; NP_001030129; NP_001277223;
	NP_001277224; NP_001277225; NP_001277226; NP_001277227; NP_006425; NP_056200; NP_079267; NP_001364126; NP_001364127; NP_001364128; NP_001364129; NP_001364130; NP_001364131; NP_001364132; NP_001364133; NP_001364134; NP_001364135; NP_001364136; NP_001364137; NP_001364138
NP_001030134; NP_001030135; NP_001030136; NP_033192; NP_848139;
	NP_001389984; NP_001389985
	Wikidata
View/Edit Human	View/Edit Mouse

CAP/Ponsin protein, also known as Sorbin and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SORBS1 gene. It is part of a small family of adaptor proteins that regulate cell adhesion, growth factor signaling and cytoskeletal formation. It is mainly expressed in heart, skeletal muscle, liver, adipose tissue, and macrophages; in striated muscle tissue, it is localized to costamere structures.