SORBS2

SORBS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IGZ
Identifiers
Aliases	SORBS2, ARGBP2, PRO0618, sorbin and SH3 domain containing 2
External IDs	OMIM: 616349; MGI: 1924574; HomoloGene: 83295; GeneCards: SORBS2; OMA:SORBS2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	185,956,652 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	46,280,943 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; popliteal artery; ; tibial arteries; ; myocardium of left ventricle; ; right coronary artery; ; cardiac muscle tissue of right atrium; ; retinal pigment epithelium; ; right adrenal cortex; ; left adrenal cortex; ; apex of heart;
	Top expressed in
	otolith organ; ; utricle; ; gastrula; ; myocardium of ventricle; ; atrioventricular valve; ; decidua; ; atrium; ; parotid gland; ; piriform cortex; ; left ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of cytoskeleton; protein binding; cytoskeletal anchor activity; structural constituent of muscle; RNA binding; nucleic acid binding;
Cellular component	cytoplasm; cell projection; membrane; focal adhesion; plasma membrane; cell junction; Z discdkac; apical plasma membrane; actin cytoskeleton; perinuclear region of cytoplasm; nucleus; lamellipodium; nucleoplasm;
Biological process	cell growth involved in cardiac muscle cell development; actin filament organization; Notch signaling pathway; biological process;
	Sources:Amigo / QuickGO
Orthologs
	8470
	234214
	ENSG00000154556
	ENSMUSG00000031626
	O94875
	Q3UTJ2
NM_001145670; NM_001145671; NM_001145672; NM_001145673; NM_001145674;
	NM_001145675; NM_001270771; NM_003603; NM_021069
	NM_001205219; NM_172752; NM_001310707; NM_001310708
NP_001139142; NP_001139143; NP_001139144; NP_001139145; NP_001139146;
	NP_001139147; NP_001257700; NP_003594; NP_066547
NP_001192148; NP_001297636; NP_001297637; NP_766340; NP_001389592;
	NP_001389593; NP_001389594; NP_001389595; NP_001389596; NP_001389597; NP_001389598; NP_001389599; NP_001389600; NP_001389601; NP_001389602; NP_001389603; NP_001389604
	Wikidata
View/Edit Human	View/Edit Mouse

ArgBP2 protein, also referred to as Sorbin and SH3 domain-containing protein 2 is a protein that in humans is encoded by the SORBS2 gene. ArgBP2 belongs to the a small family of adaptor proteins having sorbin homology (SOHO) domains. ArgBP2 is highly abundant in cardiac muscle cells at sarcomeric Z-disc structures, and is expressed in other cells at actin stress fibers and the nucleus.