Sortilin 1

SORT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3F6K, 3G2U, 3G2V, 4MSL, 4N7E, 4PO7
Identifiers
Aliases	SORT1, Gp95, LDLCQ6, NT3, NTR3, Sortilin 1
External IDs	OMIM: 602458; MGI: 1338015; HomoloGene: 136097; GeneCards: SORT1; OMA:SORT1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	109,397,918 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	108,268,827 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; corpus epididymis; ; subthalamic nucleus; ; postcentral gyrus; ; globus pallidus; ; external globus pallidus; ; internal globus pallidus; ; pars reticulata; ; corpus callosum; ; superior vestibular nucleus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; ascending aorta; ; granulocyte; ; muscle of thigh; ; lumbar subsegment of spinal cord; ; aortic valve; ; spermatid; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nerve growth factor receptor activity; neurotensin receptor activity, non-G protein-coupled; nerve growth factor binding; protein binding; enzyme binding;
Cellular component	integral component of membrane; endosome; Golgi apparatus; nuclear membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; plasma membrane; Golgi cisterna membrane; cell surface; lysosomal membrane; soma; dendrite; early endosome; endoplasmic reticulum; perinuclear region of cytoplasm; clathrin-coated pit; trans-Golgi network transport vesicle; lysosome; endosome membrane; clathrin-coated vesicle; nucleus; cytosol; cytoplasmic vesicle membrane; cytoplasmic vesicle;
Biological process	G protein-coupled receptor signaling pathway; cell differentiation; myotube differentiation; negative regulation of fat cell differentiation; endocytosis; neurotrophin TRK receptor signaling pathway; ossification; endosome transport via multivesicular body sorting pathway; vesicle organization; endosome to lysosome transport; Golgi to endosome transport; positive regulation of epithelial cell apoptotic process; multicellular organism development; response to insulin; plasma membrane to endosome transport; regulation of gene expression; negative regulation of lipoprotein lipase activity; glucose import; neuropeptide signaling pathway; extrinsic apoptotic signaling pathway via death domain receptors; nerve growth factor signaling pathway; post-Golgi vesicle-mediated transport;
	Sources:Amigo / QuickGO
Orthologs
	6272
	20661
	ENSG00000134243
	ENSMUSG00000068747
	Q99523
	Q6PHU5
	NM_001205228; NM_002959
	NM_001271599; NM_019972
	NP_001192157; NP_002950
	NP_001258528; NP_064356
	Wikidata
View/Edit Human	View/Edit Mouse

Sortilin (SORT1) is a protein that in humans is encoded by the SORT1 gene on chromosome 1. This protein is a type I membrane glycoprotein in the vacuolar protein sorting 10 protein (Vps10p) family of sorting receptors. While it is ubiquitously expressed in many tissues, sortilin is most abundant in the central nervous system. At the cellular level, sortilin functions in protein transport between the Golgi apparatus, endosome, lysosome, and plasma membrane, leading to its involvement in multiple biological processes such as glucose and lipid metabolism as well as neural development and cell death. Moreover, the function and role of sortilin is now emerging in several major human diseases such as hypertension, atherosclerosis, coronary artery disease, Alzheimer’s disease, and cancer. The SORT1 gene also contains one of 27 loci associated with increased risk of coronary artery disease.