SOX4

SOX4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3U2B
Identifiers
Aliases	SOX4, EVI16, SRY-box 4, SRY-box transcription factor 4, CSS10
External IDs	OMIM: 184430; MGI: 98366; HomoloGene: 2338; GeneCards: SOX4; OMA:SOX4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	21,598,619 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	29,137,696 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; tendon of biceps brachii; ; corpus epididymis; ; beta cell; ; visceral pleura; ; lactiferous duct; ; caput epididymis; ; tibia; ; thymus;
	Top expressed in
	medial ganglionic eminence; ; Rostral migratory stream; ; vas deferens; ; human fetus; ; Gonadal ridge; ; abdominal wall; ; mandibular prominence; ; maxillary prominence; ; superior cervical ganglion; ; left lung lobe;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription cis-regulatory region binding; core promoter sequence-specific DNA binding; protein binding; protein heterodimerization activity; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; nucleoplasm; mitochondrion; nucleus;
Biological process	skeletal system development; noradrenergic neuron differentiation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; cardiac ventricle formation; glial cell development; regulation of transcription, DNA-templated; limb bud formation; regulation of protein stability; sympathetic nervous system development; somatic stem cell population maintenance; glucose homeostasis; positive regulation of canonical Wnt signaling pathway; ventricular septum morphogenesis; protein stabilization; ascending aorta morphogenesis; negative regulation of cell death; mitral valve morphogenesis; positive regulation of translation; transcription, DNA-templated; neuroepithelial cell differentiation; positive regulation of transcription, DNA-templated; positive regulation of Wnt signaling pathway; negative regulation of protein ubiquitination; heart development; pro-B cell differentiation; atrial septum primum morphogenesis; T cell differentiation; kidney morphogenesis; positive regulation of cell population proliferation; spinal cord development; positive regulation of apoptotic process; glial cell proliferation; canonical Wnt signaling pathway; positive regulation of N-terminal peptidyl-lysine acetylation; spinal cord motor neuron differentiation; cardiac right ventricle morphogenesis; neural tube formation; cellular response to glucose stimulus; endocrine pancreas development; negative regulation of cell population proliferation; positive regulation of insulin secretion; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	6659
	20677
	ENSG00000124766
	ENSMUSG00000076431
	Q06945
	Q06831
	NM_003107
	NM_009238
	NP_003098
	NP_033264
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.