Sp3 transcription factor

SP3
Identifiers
Aliases	SP3, SPR2, Sp3 transcription factor
External IDs	OMIM: 601804; MGI: 1277166; HomoloGene: 7952; GeneCards: SP3; OMA:SP3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	173,965,373 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	72,810,790 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; germinal epithelium; ; sural nerve; ; superficial temporal artery; ; mucosa of paranasal sinus; ; Achilles tendon; ; buccal mucosa cell; ; skin of hip; ; palpebral conjunctiva; ; ventricular zone;
	Top expressed in
	granulocyte; ; genital tubercle; ; left lung lobe; ; migratory enteric neural crest cell; ; hand; ; thymus; ; atrium; ; dermis; ; left colon; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; metal ion binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	PML body; transcription repressor complex; nucleus; nucleoplasm; protein-DNA complex;
Biological process	megakaryocyte differentiation; regulation of transcription, DNA-templated; ossification; lung development; embryonic placenta development; in utero embryonic development; negative regulation of transcription by RNA polymerase II; monocyte differentiation; protein sumoylation; transcription, DNA-templated; embryonic skeletal system development; positive regulation of transcription, DNA-templated; embryonic process involved in female pregnancy; T cell differentiation; granulocyte differentiation; embryonic camera-type eye morphogenesis; trophectodermal cell differentiation; enucleate erythrocyte differentiation; erythrocyte differentiation; definitive hemopoiesis; liver development; B cell differentiation; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; natural killer cell differentiation; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6670
	20687
	ENSG00000172845
	ENSMUSG00000027109
	Q02447; Q86TP0
	O70494
	NM_003111; NM_001017371; NM_001172712
	NM_001018042; NM_001098425; NM_011450
	NP_001017371; NP_001166183; NP_003102; NP_003102.1
	NP_001018052; NP_001091895
	Wikidata
View/Edit Human	View/Edit Mouse

Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by.

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.