Sperm-associated antigen 8

SPAG8
Identifiers
Aliases	SPAG8, BS-84, CILD28, CT142, HSD-1, SMP1, SPAG3, hSMP-1, sperm associated antigen 8
External IDs	OMIM: 605731; MGI: 3056295; HomoloGene: 8250; GeneCards: SPAG8; OMA:SPAG8 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	35,812,272 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	43,653,594 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; tendon of biceps brachii; ; olfactory zone of nasal mucosa; ; left testis; ; right testis; ; bronchial epithelial cell; ; mucosa of paranasal sinus; ; Epithelium of choroid plexus; ; anterior pituitary; ; buccal mucosa cell;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; embryo; ; embryo; ; otolith organ; ; utricle; ; olfactory epithelium; ; right lung lobe; ; Epithelium of choroid plexus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; molecular function; microtubule binding;
Cellular component	acrosomal vesicle; membrane; cytoplasmic vesicle; cytoskeleton; cytoplasm; nucleus; spindle;
Biological process	single fertilization; cell differentiation; spermatogenesis; cell cycle; biological process; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	26206
	433700
	ENSG00000137098
	ENSMUSG00000066196
	Q99932
	Q3V0Q6
	NM_001039592; NM_012436; NM_172312
	NM_001007463; NM_001290462
	NP_001034681; NP_758516; NP_001353689
	NP_001007464; NP_001277391
	Wikidata
View/Edit Human	View/Edit Mouse

Sperm-associated antigen 8 is a protein that in humans is encoded by the SPAG8 gene.

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.