SPG11

SPG11
Identifiers
Aliases	SPG11, KIAA1840, ALS5, CMT2X, spastic paraplegia 11 (autosomal recessive), spatacsin vesicle trafficking associated, SPG11 vesicle trafficking associated, spatacsin
External IDs	OMIM: 610844; MGI: 2444989; HomoloGene: 41614; GeneCards: SPG11; OMA:SPG11 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	44,663,688 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	121,948,867 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; granulocyte; ; Achilles tendon; ; epithelium of nasopharynx; ; skin of thigh; ; epithelium of colon; ; corpus callosum; ; pylorus; ; spleen; ; right lobe of thyroid gland;
	Top expressed in
	granulocyte; ; spermatocyte; ; ascending aorta; ; tail of embryo; ; genital tubercle; ; aortic valve; ; ventricular zone; ; spermatid; ; yolk sac; ; lip;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; axon; lysosomal membrane; plasma membrane; dendrite; nucleolus; extracellular exosome; cytoplasmic vesicle; nucleus; cell projection; synapse; cytosol;
Biological process	axon extension; chemical synaptic transmission; synaptic vesicle transport; axo-dendritic transport; lysosome organization; phagosome-lysosome fusion involved in apoptotic cell clearance; walking behavior;
	Sources:Amigo / QuickGO
Orthologs
	80208
	214585
	ENSG00000104133
	ENSMUSG00000033396
	Q96JI7
	Q3UHA3
	NM_001160227; NM_025137
	NM_145531; NM_172533
	NP_001153699; NP_079413
	NP_663506
	Wikidata
View/Edit Human	View/Edit Mouse

Spatacsin is a protein that in humans is encoded by the SPG11 gene.