Paraplegin

SPG7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QZ4
Identifiers
Aliases	SPG7, CAR, CMAR, PGN, SPG5C, paraplegin matrix AAA peptidase subunit, SPG7 matrix AAA peptidase subunit, paraplegin
External IDs	OMIM: 602783; MGI: 2385906; HomoloGene: 31133; GeneCards: SPG7; OMA:SPG7 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	89,557,766 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	123,824,499 bp
RNA expression pattern
	Top expressed in
	gonad; ; sural nerve; ; left lobe of thyroid gland; ; apex of heart; ; right lobe of thyroid gland; ; gastric mucosa; ; right hemisphere of cerebellum; ; anterior pituitary; ; left ovary; ; right ovary;
	Top expressed in
	neural layer of retina; ; spermatocyte; ; muscle of thigh; ; interventricular septum; ; spermatid; ; right kidney; ; superior frontal gyrus; ; lip; ; primary visual cortex; ; skeletal muscle tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; nucleotide binding; peptidase activity; zinc ion binding; metalloendopeptidase activity; protein binding; hydrolase activity; ATP binding; metallopeptidase activity; metal ion binding;
Cellular component	integral component of membrane; mitochondrion; membrane; mitochondrial inner membrane; mitochondrial permeability transition pore complex; m-AAA complex; axon cytoplasm;
Biological process	proteolysis; nervous system development; mitochondrial calcium ion transmembrane transport; regulation of mitochondrial membrane permeability; mitochondrial outer membrane permeabilization involved in programmed cell death; mitochondrion organization; anterograde axonal transport;
	Sources:Amigo / QuickGO
Orthologs
	6687
	234847
	ENSG00000197912
	ENSMUSG00000000738
	Q9UQ90
	Q3ULF4
	NM_003119; NM_199367; NM_001363850
	NM_153176; NM_001364435
	NP_003110; NP_955399; NP_001350779
	NP_694816; NP_001351364
	Wikidata
View/Edit Human	View/Edit Mouse

Paraplegin is a protein that in humans is encoded by the SPG7 gene located on chromosome 16.