SPINK1

SPINK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CGI, 1CGJ, 1HPT
Identifiers
Aliases	SPINK1, PCTT, PSTI, Spink3, TATI, TCP, serine peptidase inhibitor, Kazal type 1, serine peptidase inhibitor Kazal type 1
External IDs	OMIM: 167790; MGI: 106202; HomoloGene: 68300; GeneCards: SPINK1; OMA:SPINK1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	147,831,671 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	43,870,622 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; pancreatic ductal cell; ; beta cell; ; duodenum; ; jejunal mucosa; ; rectum; ; mucosa of transverse colon; ; mucosa of sigmoid colon; ; pylorus;
	Top expressed in
	seminal vesicula; ; intestinal villus; ; epithelium of small intestine; ; ileum; ; right kidney; ; left colon; ; human kidney; ; pyloric antrum; ; jejunum; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; endopeptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity;
Cellular component	extracellular region; acrosomal vesicle; extracellular exosome; extracellular space;
Biological process	negative regulation of nitric oxide mediated signal transduction; regulation of acrosome reaction; negative regulation of peptidase activity; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of serine-type endopeptidase activity; regulation of store-operated calcium entry; negative regulation of calcium ion import; sperm capacitation;
	Sources:Amigo / QuickGO
Orthologs
	6690
	20730
	ENSG00000164266
	ENSMUSG00000024503
	P00995
	P09036
	NM_003122; NM_001354966; NM_001379610
	NM_009258
	NP_003113; NP_001341895; NP_001366539
	NP_033284
	Wikidata
View/Edit Human	View/Edit Mouse

Pancreatic secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in humans is encoded by the SPINK1 gene.

Mutations in SPINK1 has been associated with hereditary pancreatitis and tropical pancreatitis. Trypsinogen is normally created and stored an inactive zymogen of trypsin in the pancreas, but occasionally will autoactivate itself. PSTI serves to cleave prematurely activated trypsin to prevent the enzyme from causing cellular damage to the organ. Without the function of PSTI, the pancreas is subject to repeated episodes of damage.

It has also been associated with prostate cancer.