SPINT2

SPINT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4U32
Identifiers
Aliases	SPINT2, DIAR3, HAI-2, HAI2, Kop, PB, serine peptidase inhibitor, Kunitz type, 2, serine peptidase inhibitor, Kunitz type 2
External IDs	OMIM: 605124; MGI: 1338031; HomoloGene: 7955; GeneCards: SPINT2; OMA:SPINT2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	38,292,615 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,981,337 bp
RNA expression pattern
	Top expressed in
	beta cell; ; mucosa of transverse colon; ; parotid gland; ; pituitary gland; ; anterior pituitary; ; olfactory zone of nasal mucosa; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; right uterine tube; ; right testis;
	Top expressed in
	left colon; ; submandibular gland; ; intestinal villus; ; crypt of lieberkuhn of small intestine; ; pyloric antrum; ; duodenum; ; parotid gland; ; ileum; ; right kidney; ; epithelium of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity; protein binding;
Cellular component	cytoplasm; integral component of membrane; extracellular region; membrane; plasma membrane;
Biological process	negative regulation of cell motility; negative regulation of peptidase activity; negative regulation of cell-cell adhesion; establishment or maintenance of cell polarity; negative regulation of neural precursor cell proliferation; neural tube closure; negative regulation of endopeptidase activity; epithelial cell morphogenesis involved in placental branching; cellular response to BMP stimulus; basement membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	10653
	20733
	ENSG00000167642
	ENSMUSG00000074227
	O43291
	Q9WU03
	NM_021102; NM_001166103
	NM_001082548; NM_011464
	NP_001159575; NP_066925
	NP_001076017; NP_035594
	Wikidata
View/Edit Human	View/Edit Mouse

Kunitz-type protease inhibitor 2 is an enzyme inhibitor that in humans is encoded by the SPINT2 gene. SPINT2 is a transmembrane protein with two extracellular Kunitz domains to inhibit serine proteases. This gene is a presumed tumor suppressor by inhibiting HGF activator which prevents the formation of active hepatocyte growth factor. Mutations in SPINT2 could result in congenital sodium diarrhea (CSD).