Sperm microtubule associated protein 1 is a protein which in humans is encoded by the SPMAP1 gene. The protein is derived from Homo sapiens chromosome 17. The SPMAP1 gene consists of a 6,302 base sequence. Its mRNA has three exons and no alternative splice sites. The protein has 154 amino acids, with no abnormal amino acid levels. SPMAP1 has a domain of unknown function (DUF4542) and is 17.6kDa in weight. SPMAP1 does not belong to any other families nor does it have any isoforms. The protein has orthologs with high percent similarity in mammals and reptiles. The protein has additional distantly related orthologs across the metazoan kingdom, culminating with the sponge family.
Like most proteins, SPMAP1 is known to be highly expressed in the testes. The protein has also been known to have elevated levels in cancer. The protein has been shown to be expressed in proximity to or within intermediate filaments and the nucleolus. Additionally, SPMAP1 has transcription factors which are also active in hematopoietic stem cells, the immune system, and the cardiovascular system, among others. The gene is over-expressed in many cancer types, including kidney renal clear cell carcinoma and lung squamous cell carcinoma. Motif and transcription factor analysis points towards SPMAP1 playing a role in proliferation, specially in immune cell proliferation.
