SPOP

SPOP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CR2, 3HQH, 3HQI, 3HQL, 3HQM, 3HTM, 3HU6, 3IVB, 3IVQ, 3IVV, 4EOZ, 4HS2, 4J8Z, 4O1V
Identifiers
Aliases	SPOP, BTBD32, TEF2, speckle type BTB/POZ protein, NEDMIDF, NSDVS1, NSDVS2, NEDMACE
External IDs	OMIM: 602650; MGI: 1343085; HomoloGene: 68354; GeneCards: SPOP; OMA:SPOP - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,678,163 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,384,232 bp
RNA expression pattern
	Top expressed in
	nipple; ; muscle layer of sigmoid colon; ; saphenous vein; ; pylorus; ; seminal vesicula; ; popliteal artery; ; tibial arteries; ; urethra; ; cardia; ; smooth muscle tissue;
	Top expressed in
	temporal muscle; ; triceps brachii muscle; ; cerebellar vermis; ; ankle; ; lobe of cerebellum; ; sternocleidomastoid muscle; ; neural layer of retina; ; digastric muscle; ; parotid gland; ; blood;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase binding;
Cellular component	Cul3-RING ubiquitin ligase complex; nuclear speck; nucleus; nucleoplasm; cytoplasm; SCF ubiquitin ligase complex;
Biological process	protein ubiquitination; regulation of proteolysis; negative regulation of transcription by RNA polymerase II; glucose homeostasis; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of DNA-binding transcription factor activity; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of type B pancreatic cell apoptotic process; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8405
	20747
	ENSG00000121067
	ENSMUSG00000057522
	O43791
	Q6ZWS8
NM_001007226; NM_001007227; NM_001007228; NM_001007229; NM_001007230;
	NM_003563; NM_001370730; NM_001370731; NM_001370732
	NM_025287; NM_001359107
NP_001007227; NP_001007228; NP_001007229; NP_001007230; NP_001007231;
	NP_003554; NP_001357659; NP_001357660; NP_001357661
	NP_079563; NP_001346036
	Wikidata
View/Edit Human	View/Edit Mouse

Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.